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US 5,349,001 AGranted
Cyclic imide thione activated polyalkylene oxides
AssigneeEnzon, Inc.
InventorsRichard B. Greenwald, Anthony J. Martinez
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Abstract
Water-soluble cyclic imide thione activated polyalkylene oxides having improved hydrolytic stability are disclosed. Methods of forming and conjugating the activated polyalkylene oxides with biologically active nucleophiles are also disclosed.
Claims10
A water-soluble cyclic imide thione activated polyalkylene oxide, comprising a structure represented by:
- X--R--L--CO--R.sub.3
- wherein:
- R is a polyalkylene oxide residue having a number average molecular weight between 600 and 100,000 daltons;
- R.sub.3 is selected from the group consisting of:
- ##STR7## L is a moiety forming a covalent linkage between R and the carbonyl carbon, said moiety being hydrolytically stable at physiologic pH and temperatures up to 27.degree. C.;
- and
- X is a terminal moiety of said polyalkylene oxide selected from the group consisting of alkoxy moieties containing up to four carbon atoms and --L--CO--R.sub.3.
4 more elements
Dependencies are inferred from the claim text.