# US 5,348,959 A · Use of dicentrine and its derivatives for the treatment of hypertension, arrhythmia, thrombosis and atherosclerosis

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- Number: US 5,348,959 A
- Document ID: US5348959A
- Status: Granted
- Kind: A
- Application number: 08/053,665
- Filed: 1993-04-29
- Granted: 1994-09-20
- Earliest claimed: 1991-12-02
- Assignees: National Science Council
- Inventors: Che-Ming Teng; Chien-Chih Chen; Sheu-Meei Yu
- Web page: https://patentgrep.com/patent/US5348959A

## CPC

- A61K 31/47: Quinolines; Isoquinolines
- A61K 36/54: Lauraceae (Laurel family), e.g. cinnamon or sassafras
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A method for the treatment of hypertension, arrhythmia, thrombosis or/and atherosclerosis with an effective amount of dicentrine or other alkaloids extracted from Lindera oldhammii (megaphylla) Hemsl.

## Claims

### Claim 1

A method for treating atherosclerosis in a subject in need thereof, comprising administering to said subject a pharmaceutical composition which comprises an effective amount of dicentrine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

### Claim 2 (depends on 1)

The method of claim 1, wherein the effective amount is administered orally in solid dosage form.

### Claim 3 (depends on 1)

The method of claim 1, wherein the effective amount is administered orally in liquid dosage form.

### Claim 4 (depends on 1)

The method of claim 1, wherein the effective amount is administered parenterally.