# US 5,348,943 A · Cosmetic and skin treatment compositions

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- Number: US 5,348,943 A
- Document ID: US5348943A
- Status: Granted
- Kind: A
- Application number: 07/924,324
- Filed: 1992-08-03
- Granted: 1994-09-20
- Earliest claimed: 1985-02-08
- Assignees: ProCyte Corporation
- Inventors: Loren R. Pickart
- Web page: https://patentgrep.com/patent/US5348943A

## CPC

- A61K 8/19: containing inorganic ingredients
- A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof
- A61Q 7/00: Preparations for affecting hair growth
- A61Q 19/02: for chemically bleaching or whitening the skin
- C07K 5/0827: {containing heteroatoms different from O, S, or N}
- A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00)
- A61K 2800/58: Metal complex; Coordination compounds
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

## Abstract

Methods and compositions for (a) improving and/or maintaining the health of skin, and (b) increasing subcutaneous fat in warm-blooded animals are disclosed. The methods utilize an effective amount of a composition comprising GHL--Cu or a derivative of GHL--Cu.

## Claims

### Claim 1

A skin treatment composition, comprising GHL--Cu or a derivative of GHL--Cu having the formula: ##STR4## wherein R is selected from the group consisting of alkyl moieties containing from 1 to 18 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 12 carbon atoms, and aryloxy moieties containing from 6 to 18 carbon atoms, or where R is L-prolyl-L-valyl-L-phenylalanyl-L-valine or L-valyl-L-phenylalanyl-L-valine, in combination with a cosmetically and dermatologically acceptable carrier or diluent.

### Claim 2 (depends on 1)

The composition of claim 1 wherein the carbon portion of the alkoxy moiety is an unbranched chain.

### Claim 3 (depends on 2)

The composition of claim 2 wherein the unbranched chain is an n-octyl moiety.

### Claim 4 (depends on 2)

The composition of claim 2 wherein the unbranched chain is an n-stearyl moiety.

### Claim 5 (depends on 2)

The composition of claim 2 wherein the unbranched chain is an n-palmityl moiety.

### Claim 6 (depends on 1)

The composition of claim 1 wherein the aryloxy moiety is an O-benzyl moiety.