# US 5,348,747 A · Pharmaceutical coating sugars > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 5,348,747 A - Document ID: US5348747A - Status: Granted - Kind: A - Application number: 08/011,844 - Filed: 1993-02-01 - Granted: 1994-09-20 - Earliest claimed: 1992-03-05 - Assignees: American Home Products Corporation - Inventors: Giustino Bianco - Web page: https://patentgrep.com/patent/US5348747A ## CPC - A61K 9/167: {with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface (with further drug-free outer coating A61K9/5073)} - A61K 9/1676: {having a drug-free core with discrete complete coating layer containing drug (adsorbates of liquid drug formulations on inert powders without simultaneous granulation step A61K9/141; with further drug-free outer coating A61K9/5078; drug conjugated to non-active particles A61K47/6921)} - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) ## Abstract A finely divided solid pharmaceutical dosage form for oral administration dissolved or suspended in a pharmaceutically acceptable liquid is described which pharmaceutical dosage form consists of a pharmaceutical coating on a sugar core. ## Claims ### Claim 1 A finely divided water soluble solid pharmaceutical dosage form having a particle size smaller than 10 mesh for immediate release of the pharmaceutical by oral administration of a pharmaceutically acceptable liquid having the water-soluble solid pharmaceutical dosage form dissolved therein, the pharmaceutical dosage form consisting of a pharmaceutical coating on a sugar core wherein: a) the sugar core consists essentially of about 90% to 100% by weight of sugar based on the weight of the sugar core, the sugar having a particle size of 30-60 mesh and the sugar core comprising about 90% to about 99% by weight of the pharmaceutical dosage form; b) the pharmaceutical coating consists essentially of about 25% to about 50% by weight of sugar based on the dry weight of the coating and about 50% to about 75% by weight of at least one water-soluble pharmaceutical based on the dry weight of the coating and the coating comprising about 1% to about 5% by weight of the pharmaceutical dosage form; and c) the pharmaceutical coating having been applied to the sugar core from an aqueous solution of the sugar and the water-soluble pharmaceutical containing about 50% to 80% by weight of water by pan coating such that the surface of the sugar core is dissolved and intimately admixed with the coating solution thereby forming an intimate bond between the sugar core and the water-soluble pharmaceutical. ### Claim 2 (depends on 1) The finely divided solid pharmaceutical dosage form of claim 1 wherein the pharmaceutical coating contains at least one water-soluble medicament selected from the group consisting of antihistamines, decongestants, cough suppressants and bronchodilators. ### Claim 3 (depends on 1) The finely divided solid pharmaceutical dosage form of claim 1 wherein the sugar core additionally contains at least one medicament selected from the group consisting of nonnarcotic analgesics and nonsteroidal antiinflammatories. ### Claim 4 (depends on 1) The finely divided solid pharmaceutical dosage form of claim 1 wherein the sugar is sucrose and the pharmaceutical coating having been applied to the sugar core from an aqueous solution of the sugar and the water-soluble pharmaceutical containing at least about 70% by weight of water. ### Claim 5 (depends on 4) The finely divided solid pharmaceutical dosage form of claim 4 wherein the pharmaceutical coating contains at least one water-soluble medicament selected from the group consisting of antihistamines, decongestants, cough suppressants and bronchodilators. ### Claim 6 (depends on 4) The finely divided solid pharmaceutical dosage form of claim 4 wherein the sugar core additionally contains at least one medicament selected from the group consisting of nonnarcotic analgesics and nonsteroidal antiinflammatories. ### Claim 7 (depends on 6) The finely divided solid pharmaceutical dosage form of claim 6 wherein the sugar core contains a nonnarcotic analgesic. ### Claim 8 (depends on 7) The finely divided solid pharmaceutical dosage form of claim 7 wherein the pharmaceutical coating contains at least one water-soluble medicament selected from the group consisting of antihistamines, decongestants and cough suppressants. ### Claim 9 (depends on 4) The finely divided solid pharmaceutical dosage form of claim 4 wherein the sugar core contains a nonnarcotic analgesic and the pharmaceutical coating contains at least one water-soluble medicament selected from the group consisting of antihistamines, decongestants and cough suppressants. ### Claim 10 (depends on 9) The finely divided solid pharmaceutical dosage form of claim 9 wherein the sugar core contains acetaminophen and the pharmaceutical coating contains pseudoephedrine hydrochloride and dextromethorphan hydrobromide. ### Claim 11 (depends on 9) The finely divided solid pharmaceutical dosage form of claim 9 wherein the sugar core contains acetaminophen and the pharmaceutical coating contains pseudoephedrine hydrochloride, diphenylhydramine hydrochloride and dextromethorphan hydrobromide.