# US 5,348,744 A · Antidiarrheal compositions containing loperamide hydrochloride and a saccharide

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- Number: US 5,348,744 A
- Document ID: US5348744A
- Status: Granted
- Kind: A
- Application number: 07/944,232
- Filed: 1992-09-14
- Granted: 1994-09-20
- Earliest claimed: 1990-10-24
- Assignees: SS Pharmaceutical Co., Ltd.
- Inventors: Toshiaki Kurazumi; Hiroyuki Mizuno; Katsumi Imamori; Akira Iwasa
- Web page: https://patentgrep.com/patent/US5348744A

## CPC

- A61K 9/0095: {Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches (A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006)}
- A61K 31/445: Non condensed piperidines, e.g. piperocaine
- A61P 1/12: Antidiarrhoeals
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Described herein are antidiarrheal compositions containing loperamide hydrochloride as an effective ingredient and a saccharide, for example, a monosaccharide, oligosaccharide or sugar alcohol in an amount as much as at least 3,000 times the weight of loperamide hydrochloride.

## Claims

### Claim 1

An antidiarrheal composition, comprising an amount of a mixture of loperamide hydrochloride and a saccharide selected from the group consisting of fructose, glucose, sucrose, sorbitol, xylitol, mannitol and mixtures thereof effective for the control of diarrhea, said loperamide hydrochloride being present in an amount of from 0.0003 to 0.001 wt. % of said composition and said saccharide being present in an amount of from 9 to about 98 wt. % of said composition and from 20,000 times to 50,000 times the weight of said loperamide hydrochloride.

### Claim 2 (depends on 1)

The antidiarrheal composition of claim 1, wherein said saccharide is present in an amount of from 30 to 97.995 wt. % of said composition.

### Claim 3 (depends on 2)

The antidiarrheal composition of claim 2, wherein said saccharide is present in an amount of from 30 to 45 wt. % of said composition.

### Claim 4 (depends on 3)

The antidiarrheal composition of claim 3, wherein said loperamide hydrochloride is present in an amount of from 0.003 to 0.005 wt. % of said composition.

### Claim 5 (depends on 1)

The antidiarrheal composition of claim 1, wherein said loperamide hydrochloride is present in a dosage of from 0.03 to 1.0 mg/kg.

### Claim 6 (depends on 1)

The antidiarrheal composition of claim 1, whose preparation form is a syrup or a suspended syrup.