# US 5,348,733 A · Oral composition

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- Number: US 5,348,733 A
- Document ID: US5348733A
- Status: Granted
- Kind: A
- Application number: 07/971,593
- Filed: 1992-11-05
- Granted: 1994-09-20
- Earliest claimed: 1991-11-06
- Assignees: Lion Corporation
- Inventors: Seiji Morishima; Miwako Oka; Yamazaki Yoji
- Web page: https://patentgrep.com/patent/US5348733A

## CPC

- A61K 8/19: containing inorganic ingredients
- A61K 8/347: {Phenols}
- A61K 8/463: {containing sulfuric acid derivatives, e.g. sodium lauryl sulfate}
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

An oral composition comprises triclosan, an alkyl sulfate and a water-soluble tin salt, whereby triclosan can be stably formulated to exert its effect.

## Claims

### Claim 1

An oral composition consisting essentially of:
0.001 to 1.0% by weight of the total weight of the oral composition of triclosan;
0.01 to 10% by weight of the total weight of the oral composition of an alkyl sulfate;
0.01 to 10% by weight of the total weight of the oral composition of a water-soluble tin salt selected from the group consisting of stannous fluoride, stannous chloride, stannous fluoride chloride, stannous acetate, stannous sulfate, stannous tartrate, stannous gluconate and stannous citrate; and
one or more optional effective ingredients in an amount not impeding the germicidal effect of triclosan selected from the group consisting of abrasives, binders, humectants and flavors.

### Claim 2 (depends on 1)

The oral composition according to claim 1, wherein the alkyl sulfate has 8 to 18 carbon atoms in the alkyl group.

### Claim 3 (depends on 1)

The oral composition according to claim 1, wherein said composition is in the form of a member selected from the group consisting of toothpaste, toothpowder, mouthwash, gingiva-massage cream, ointment, troche, and chewing gum.

### Claim 4 (depends on 1)

The oral composition according to claim 1, wherein the triclosan is present in an amount of from 0.01 to 0.05% by weight of the total weight of the oral composition,
the alkyl sulfate is present in the amount of from 0.1 to 5% by weight of the total weight of the oral composition, and
the water-soluble tin salt is present in the amount of 0.1 to 2% by weight of the total weight of the oral composition.

### Claim 5 (depends on 1)

The oral composition according to claim 1, wherein the alkyl sulfate has 10 to 14 carbon atoms in the alkyl group.

### Claim 6 (depends on 1)

The oral composition according to claim 1, wherein the alkyl sulfate is selected from the group consisting of sodium lauryl sulfate and sodium myristyl sulfate.

### Claim 7 (depends on 1)

The oral composition according to claim 1, wherein the water-soluble tin salt is selected from the group consisting of stannous fluoride, stannous chloride and stannous gluconate.

### Claim 8 (depends on 1)

The oral composition according to claim 1, wherein the pH is from 5 to 6.5.

### Claim 9 (depends on 1)

The oral composition according to claim 1, wherein the alkyl sulfate is sodium lauryl sulfate and the water-soluble tin salt is stannous fluoride.

### Claim 10 (depends on 1)

The oral composition according to claim 1, wherein the water-soluble tin salt is stannous fluoride and the oral composition is in the form of a toothpaste.