# US 5,348,060 A · Drug vessel > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 5,348,060 A - Document ID: US5348060A - Status: Granted - Kind: A - Application number: 07/917,942 - Filed: 1992-07-24 - Granted: 1994-09-20 - Earliest claimed: 1991-08-08 - Assignees: Nissho Corporation - Inventors: Hitoshi Futagawa; Koji Ikeda; Toshihiro Kikuchi - Web page: https://patentgrep.com/patent/US5348060A ## CPC - A61J 1/2089: {Containers or vials which are to be joined to each other in order to mix their contents (combinations of vial and syringe for mixing their contents A61J1/2096)} - A61J 1/2041: {having removable plugs} - Y10S 215/08: Mixing - A61J: CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE - Y10S: TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS ## Abstract A drug vessel suitable for aseptic mixing of a drug with a solvent or diluent and for parenteral administration of the resultant solution, which includes a cylindrical vessel body reduced in diameter at both sides thereof to form a narrow mouth portion at each end, and a seal member to be attached to each mouth portion of the vessel body for sealing the same. ## Claims ### Claim 1 A drug vessel for use in combination with a solvent containers, comprising: a cylindrical vessel body having upper and lower mouth portions reduced in diameter, said lower mouth portion being provided on its outer periphery with a male screw thread for complementary engagement with a solvent container and a circumferential groove for receiving a sealing ring; upper and lower sealing members for closing said upper and lower mouth portions, said lower sealing member being provided in its lower end with a recess for engagement with a pushing rod of a solvent container; to prevent the lower sealing member from falling into the solvent container upon engagement of said vessel with said container; clamping means for retaining said upper sealing member within the vessel and for keeping said upper mouth portion in an aseptic condition; and a cap removably attached to said lower mouth for keeping said lower mouth portion in an aseptic condition. ### Claim 2 (depends on 1) The drug vessel according to claim 1, wherein at least one of said sealing members comprises a rubber stopper. ### Claim 3 (depends on 1) The drug vessel according to claim 1, wherein said cap is screwed onto at least the lower mouth portion of said vessel body. ### Claim 4 (depends on 1) The drug vessel according to claim 1, wherein said drug vessel is covered with a synthetic sheet. ### Claim 5 (depends on 1) The drug vessel according to claim 1, wherein one of said sealing members comprise a rubber stopper having a cylindrical plug portion and an enlarged flange-like head portion integrally connected to one end thereof and wherein the other sealing member comprises a rubber stopper having a cylindrical plug portion with a central recess. ### Claim 6 (depends on 1) The drug vessel according to claim 1, wherein said upper sealing member comprises a rubber stopper. ### Claim 7 (depends on 6) The drug vessel according to claim 6, wherein said upper rubber stopper is composed of a cylindrical plug portion and an enlarged flange-like head portion. ### Claim 8 (depends on 1) The drug vessel according to claim 1, wherein said lower sealing member is composed of a rubber stopper. ### Claim 9 (depends on 1) The drug vessel according to claim 1, wherein the recess of said lower sealing member is a cylindrical recess. ### Claim 10 (depends on 1) The drug vessel according to claim 1, wherein the recess of said lower sealing member is a threaded recess. ### Claim 11 (depends on 1) The drug vessel according to claim 1, wherein said clamping means is comprised of aluminum in the form of a cap-like member having two or more arc-shaped narrow openings. ### Claim 12 (depends on 1) The drug vessel according to claim 1, wherein said cap is screw-mounted on the lower mouth portion of said vessel body. ### Claim 13 (depends on 1) The drug vessel according to claim 1, wherein said cap is a bottom-closed cylindrical member having an enlarged portion at the upper side thereof and being fixed to said vessel body at said enlarged portion. ### Claim 14 (depends on 13) The drug vessel according to claim 13, wherein the enlarged portion of said cap is provided with projections extending downward. ### Claim 15 (depends on 13) The drug vessel according to claim 13, wherein said cap is provided with a circumferential weakened part immediately adjacent to said enlarged portion so that the cap can be twisted off easily by turning it, while leaving the enlarged portion on the vessel. ### Claim 16 (depends on 1) The drug vessel according to claim 1, wherein said drug vessel is wholly covered with a synthetic sheet. ### Claim 17 A drug transfusion set comprising a drug vessel and a solvent container assembly adapted to be connected to said drug vessel, said drug vessel comprising a cylindrical vessel body having upper and lower mouth portions reduced in diameter, said lower mouth portion being provided on its outer periphery with a male screw thread for complementary engagement with a solvent container and having a circumferential groove for receiving a sealing ring, upper and lower sealing members for closing said upper and lower mouth portions, said lower sealing member being provided in its lower end with a recess for engagement with a pushing rod of a solvent container to prevent the lower sealing member from falling in the solvent container, clamping means for retaining said upper sealing member and for keeping said upper mouth portion in an aseptic condition, and a cap removably attached to said lower mouth for keeping said lower mouth portion in an aseptic condition, said solvent container comprising a closed end and an open end and a connecting member fixed to the open end of the container, the open end of said solvent container being closed by said connecting member. ### Claim 18 (depends on 17) The drug transfusion set according to claim 17, wherein said cap is a bottom-closed cylindrical member having an enlarged portion at the upper side thereof and being fixed to said vessel body at said enlarged portion. ### Claim 19 (depends on 18) The drug transfusion set according to claim 18, wherein the enlarged portion of said cap is provided with projections extending downward. ### Claim 20 (depends on 19) The drug transfusion set according to claim 19, wherein said connecting member is provided with a plurality of projections adapted to be engaged with the projections of the enlarged portion of said cap. ### Claim 21 (depends on 18) The drug transfusion set according to claim 18, wherein said cap is provided with a circumferential weakened part immediately adjacent to said enlarged portion so that the cap can be twisted off easily by turning it, while leaving the enlarged portion on the vessel. ### Claim 22 (depends on 17) The drug transfusion set according to claim 17, wherein said connecting member has a bore corresponding to a configuration of the lower half of the drug vessel and having a female screw thread for complementary engagement with the male thread of said drug vessel. ### Claim 23 (depends on 17) The drug transfusion set according to claim 17, wherein said connecting member has a partition wall having a push rod integrally formed therewith, said partition wall being arranged near a lower end of said connecting member, said push rod being formed coaxially with respect to the center axis of the connecting member and extending in the direction toward the open end of the connecting member. ### Claim 24 (depends on 23) The drug transfusion set according to claim 23, wherein said push rod is adapted to be fitted in the recess of said lower sealing member. ### Claim 25 (depends on 23) The drug transfusion set according to claim 23, wherein said push rod is provided with a male screw at a free end thereof and adapted to be screwed in the threaded recess of said lower sealing member. ### Claim 26 (depends on 23) The drug transfusion set according to claim 23, wherein said partition wall has an annular weakened portion formed coaxially with the pushing rod to allow the partition wall to be easily broken by the lower mouth portion of the drug vessel. ### Claim 27 (depends on 26) The drug transfusion set according to claim 26, wherein said partition wall is provided in its both sides with several grooves radially extending from the base of said pushing rod towards the weakened portion to form passages for the solvent when the partition wall is pressed against the open end of the solvent container. ### Claim 28 (depends on 17) The drug transfusion set according to claim 17, wherein the upper open end of the connecting member is sealed by a laminated film.