# US 5,347,037 A · (RR) and (RS stereoisomers of N-(7-ethoxycarbonylmethoxy-1,2,3,-tetrahydronaphth-2-yl)-2-(3-chlorophen yl)-2-hydroxyethanamine and their pharmaceutically acceptable salts

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- Number: US 5,347,037 A
- Document ID: US5347037A
- Status: Granted
- Kind: A
- Application number: 08/114,190
- Filed: 1993-09-01
- Granted: 1994-09-13
- Earliest claimed: 1987-08-12
- Assignees: Sanofi
- Inventors: Robert Boigegrain; Roberto Cecchi; Sergio Boveri
- Web page: https://patentgrep.com/patent/US5347037A

## CPC

- C07C 213/06: from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups
- C07C 217/74: with rings other than six-membered aromatic rings being part of the carbon skeleton
- C07C 271/16: to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
- C07C 271/24: with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C 2602/10: the other ring being six-membered, e.g. tetraline
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

A process for the preparation of a compound of formula (I) ##STR1## which is a (RR) and (RS) stereoisomer of N-(7-ethoxycarbonylmethoxy-1,2,3,4,-tetrahydronaphth-2-yl)-2-(3-chlorophen yl)-2-hydroxyethanamine and their pharmaceutically acceptable salts.

## Claims

### Claim 1

A substantially optically pure compound which is N-[(2S)-7-ethoxycarbonylmethoxy-1,2,3,4-tetrahydronaphth-2-yl]-(2R)-2-(3-c hlorophenyl)-2-hydroxyethanamine and its pharmaceutically acceptable salts.

### Claim 2

A substantially optically pure compound which is N-[(2R)-7-ethoxycarbonylmethoxy-1,2,3,4-tetrahydronaphth-2yl]-(2R)-2-(3-ch lorophenyl)-2-hydroxyethanamine and its pharmaceutically acceptable salts.