# US 5,347,032 A · Preparation of alkyl cyanoacetates

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- Number: US 5,347,032 A
- Document ID: US5347032A
- Status: Granted
- Kind: A
- Application number: 08/100,360
- Filed: 1993-08-02
- Granted: 1994-09-13
- Earliest claimed: 1992-08-20
- Assignees: BASF SE
- Inventors: Helmut Reichelt; Clemens Grund
- Web page: https://patentgrep.com/patent/US5347032A

## CPC

- C07C 253/30: by reactions not involving the formation of cyano groups
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

A process for the preparation of C.sub.4 -C.sub.10 alkyl cyanoacetates by the reaction of cyanoacetic acid with C.sub.4 -C.sub.10 alkanols at a temperature of from 35.degree. to 150.degree. C. and under a pressure of from 70 to 1013 mbar, in the presence of catalytic amounts of acid, while a C.sub.4 -C.sub.10 alkanol/water azeotrope is separated during the reaction.

## Claims

### Claim 1

A process for the preparation of a C.sub.4 -C.sub.10 alkyl cyanoacetate by the reaction of cyanoacetic acid with a C.sub.4 -C.sub.10 alkanol, comprising reacting cyanoacetic acid in an aqueous medium, with from 5 to 30 times its molar amount of a C.sub.4 -C.sub.10 alkanol at a temperature of from 35.degree. to 150.degree. and under a pressure of from 70 to 1013 mbar, in the presence of a catalytic amount of an acid, while a C.sub.4 -C.sub.10 alkanol/water azeotrope is separated during the reaction, and wherein said cyanoacetic acid is not extracted from said aqueous medium prior to esterification.

### Claim 2 (depends on 1)

A process as claimed in claim 1, wherein cyanoacetic acid is caused to react with a C.sub.4 -C.sub.8 alkanol.

### Claim 3 (depends on 1)

A process as claimed in claim 1, wherein the reaction is carried out at a temperature of from 50.degree. to 90.degree. C.

### Claim 4 (depends on 1)

A process as claimed in claim 1, wherein the reaction is carried out under a pressure of from 70 to 270 mbar.

### Claim 5 (depends on 1)

A process as claimed in claim 1, wherein the reaction is carried out using an aqueous cyanoacetic acid solution which contains from 20 to 70 wt % of cyanoacetic acid, based on the total weight of the solution.