Radioiodinated phospholipid ether analogues and methods of using same
AssigneeThe Board of Regents of the University of Michigan
InventorsRaymond E. Counsell, Karen L. Meyer, Susan W. Schwendner, Terushi Haradahira
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Abstract
Novel radioiodinated analogues of naturally-occurring phospholipid ethers are tumor-specific and have a triglycerol backbone structure which, in certain embodiments, is substituted at the 3-position with an alkyl phosphocholine and include a monoiodinated benzoyl side chain substituted at the 2-position in accordance with the general formula: ##STR1## where n= 1-15 ##STR2## m= 0-15; Z=.sup.123 I, .sup.125 I, and .sup.131 I; Y=NH.sub.2, NR.sub.2, and NR.sub.3, and R=alkyl, aralkyl.
Claims1
The compound rac-1-O-Hexadecyl-2-O-iodobenzoyl-3-O-glycerol phosphocholine, wherein iodo is a radioactive isotope of iodine selected from the group consisting of .sup.122 I, .sup.123 I, .sup.125 I, and .sup.131 I.
Dependencies are inferred from the claim text.