# US 5,347,005 A · Pharmaceutical compositions containing (65)-folinic acid and salts thereof

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- Number: US 5,347,005 A
- Document ID: US5347005A
- Status: Granted
- Kind: A
- Application number: 07/896,482
- Filed: 1992-06-02
- Granted: 1994-09-13
- Earliest claimed: 1987-05-15
- Assignees: Eprova AG
- Inventors: Hans R. Mueller; Martin Ulmann; Josef Conti; Gunter Muerdel
- Web page: https://patentgrep.com/patent/US5347005A

## CPC

- C07D 475/04: with a nitrogen atom directly attached in position 2
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

The invention relates to a process for preparing (6S)-folinic acid and its salts by recrystallization of alkaline-earth salts of (6R,S)-folinic acid and, where necessary, liberation of the acid from the alkaline-earth folinates and/or, where necessary, conversion into the alkali salts by at least one recrystallization in the presence of a base. The invention also relates to calcium-, magnesium-, potassium- and sodium-(6S)-folinates and to (6S)-folinic acid prepared in accordance with the invention.

## Claims

### Claim 1

Magnesium salt of (6S)-folinic acid.

### Claim 2 (depends on 1)

A magnesium salt according to claim 1 having a purity of at least 95%.