# US 5,347,001 A · Process for preparing sulphonylpristinamycin II.sub.B

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- Number: US 5,347,001 A
- Document ID: US5347001A
- Status: Granted
- Kind: A
- Application number: 07/961,915
- Filed: 1993-01-04
- Granted: 1994-09-13
- Earliest claimed: 1990-07-16
- Assignees: Rhone-Poulenc Rorer S.A.
- Inventors: Xavier Radisson
- Web page: https://patentgrep.com/patent/US5347001A

## CPC

- C07K 5/06182: {and Pristinamycin II; Derivatives thereof}
- A61P 31/04: Antibacterial agents
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Method for preparing (dialkylamino-2 alkyl)sulphonyl-26 pristinamycin II.sub.B having general formula (I) ##STR1## by oxidation of (dialkylamino-2 alkyl)thio-26 pristinamycin II.sub.B with 3,5 to 20 of hydrogenperoxide equivalent, in the presence of alcaline metal tungstate, in a 2-phase medium, at a temperature between 10.degree. and 25.degree. C.

## Claims

### Claim 1

A process for preparing 26-[(2-dialkylaminoalkyl)sulphonyl]pristinamycin II.sub.B of formula: ##STR4## in which Alk represents a linear or branched alkylene radical and R represents linear or branched alkyl radicals, these radicals containing 1 to 10 carbon atoms, comprising oxidation of 26-[(2-dialkylaminoalkyl)thio]-pristinamycin II.sub.B of formula: ##STR5## in which Alk and R are defined as above, with 3.5 to 20 equivalents of hydrogen peroxide in the presence of an alkali metal tungstate, in a two-phase medium, at a temperature of between 10.degree. and 25.degree. C.

### Claim 2 (depends on 1)

A process according to claim 1, wherein the alkali metal tungstate is sodium tungstate.

### Claim 3 (depends on 1)

A process according to claim 1, wherein the alkali metal tungstate is introduced in the proportion of 5 to 0.5 mol%.

### Claim 4 (depends on 1)

A process according to claim 1, wherein the two-phase medium consists of a water/chlorinated solvent or water/n-butanol mixture.