# US 5,346,890 A · Antioxidation active substance and utilization thereof

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- Number: US 5,346,890 A
- Document ID: US5346890A
- Status: Granted
- Kind: A
- Application number: 07/745,251
- Filed: 1991-08-14
- Granted: 1994-09-13
- Earliest claimed: 1990-05-14
- Assignees: Yoshihide Hagiwara
- Inventors: Yoshihide Hagiwara; Hideaki Hagiwara
- Web page: https://patentgrep.com/patent/US5346890A

## CPC

- A23L 7/109: Types of pasta, e.g. macaroni or noodles
- A21D 2/18: Carbohydrates
- A23B 2/733: Compounds of undetermined constitution obtained from animals or plants
- A23B 2/771: Organic compounds containing hetero rings
- A23C 9/13: using additives
- A23D 7/001: {Spread compositions (characterised by ingredients other than fatty acid triglycerides A23D7/0056)}
- A23L 13/428: {Addition of flavours, spices, colours, amino acids or their salts, peptides, vitamins, yeast extract or autolysate, nucleic acid or derivatives, organic acidifying agents or their salts or acidogens, sweeteners, e.g. sugars or sugar alcohols; Addition of alcohol-containing products}
- A61K 8/602: {Glycosides, e.g. rutin}
- A61Q 7/00: Preparations for affecting hair growth
- A61Q 17/04: Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
- A61Q 19/02: for chemically bleaching or whitening the skin
- C09K 15/34: containing plant or animal materials of unknown composition
- C11B 5/0035: {Phenols; Their halogenated and aminated derivates, their salts, their esters with carboxylic acids}
- C11B 5/0085: {Substances of natural origin of unknown constitution, f.i. plant extracts}
- C12H 1/14: with non-precipitating compounds, e.g. sulfiting; Sequestration, e.g. with chelate-producing compounds
- A61K 2800/522: Antioxidants; Radical scavengers
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A21D: TREATMENT OF FLOUR OR DOUGH FOR BAKING, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS (preservation of flour or dough before baking A23B40/00; preservation of bakery products A23B45/00)
- A23B: PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
- A23C: DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF (preservation thereof A23B11/00)
- A23D: EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS (preservation thereof A23B20/00; production, refinement or preservation of animal or vegetable fats or oils C11B, C11C)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- C09K: MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C11B: PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES (drying-oils C09F)
- C12H: PASTEURISATION, STERILISATION, PRESERVATION, PURIFICATION, CLARIFICATION OR AGEING OF ALCOHOLIC BEVERAGES; METHODS FOR ALTERING THE ALCOHOL CONTENT OF FERMENTED SOLUTIONS OR ALCOHOLIC BEVERAGES (simulation ageing by flavouring C12G3/06)

## Abstract

An antioxidant substance which is a green leaf component in a green plant, comprising a component which is substantially insoluble in n-hexane but soluble in an aqueous ethanol solution having a water content of 0 to 80% by volume. The substance has an antioxidant activity as potent as or more potent than .alpha.-tocopherol, and is useful as an antioxidant for use in the field of foods, and medicines. Particularly, the antioxidant substance can be used for maintaining the freshness and quality of foods or storage thereof. The substance can be blended with cosmetics for skin and hair and are useful for the prevention of spots, freckles, chapping and sunburn.

## Claims

### Claim 1

A cosmetic composition which consists essentially of a cosmetic matrix and an effective antioxidant amount of 2'-O-glucosyl-isovitexin having the formula ##STR3## in an amount of 0.001 to 1% by weight of said composition.

### Claim 2 (depends on 1)

The cosmetic composition of claim 1 which contains 0.005 to 0.5% by weight of 2'-O-glucosyl-isovitexin.

### Claim 3 (depends on 1)

The cosmetic composition of claim 1 wherein the matrix is a member selected from the group consisting of water, ethanol, propylene glycol, stearic acid, glycerol, cetyl alcohol and liquid paraffin and mixtures thereof.

### Claim 4 (depends on 1)

The cosmetic composition of claim 1 formulated as a skin lotion.

### Claim 5 (depends on 1)

The cosmetic composition of claim 1 formulated as a skin cream.

### Claim 6 (depends on 1)

The cosmetic composition of claim 1 formulated as a hair treating composition.

### Claim 7

A cosmetic skin lotion which comprises a cosmetic matrix consisting essentially of ethyl alcohol, methyl p-hydroxybenzoate, perfume, colorant and water, and an effective antioxidant amount of 2'-O-glucosyl-isovitexin.

### Claim 8 (depends on 7)

The cosmetic composition of claim 7 which contains 0.005 to 0.5% by weight of 2'-O-glucosyl-isovitexin.

### Claim 9

A cosmetic skin cream which comprises a cosmetic matrix consisting essentially of stearic acid, isopropyl myristate, cetyl alcohol, liquid paraffin, glycerol monostrearate, polyoxyethylene stearate, methyl p-hydroxybenzoate, glycerol, propylene glycol and water, and an effective antioxidant amount of 2'-O-glucosyl-isovitexin.

### Claim 10 (depends on 9)

The cosmetic composition of claim 9 which contains 0.005 to 0.5% by weight of 2'-O-glucosyl-isovitexin.

### Claim 11

A cosmetic hair treating composition comprising a cosmetic matrix consisting essentially of ethanol, propylene glycol, perfume and colorant, and an effective anti-oxidant amount of 2'-O-glucosyl-isovitexin.

### Claim 12 (depends on 11)

The cosmetic composition of claim 11 which contains 0.005 to 0.5% by weight of 2'-O-glucosyl-isovitexin.

### Claim 13

A cosmetic skin lotion composition which consists essentially of:
0.05 to 5.0 parts by weight 2'-O-glucosyl-isovitexin
100 parts by weight 95% ethanol
0.05 parts by weight methyl p-hydroxybenzoate
0.5 parts by weight perfume
0.005 parts by weight colorant
and subsequently making the composition 1000 parts by weight by adding purified water.

### Claim 14

A cosmetic skin cream composition which consists essentially of:
0.3 parts by weight 2'-O-glucosyl-isovitexin
10.0 parts by weight stearic acid
5.0 parts by weight cetyl alcohol
7.0 parts by weight liquid paraffin
2.0 parts by weight glycerol monostearate
5.0 parts by weight polyoxethylene stearate
0.1 parts by weight methyl p-hydroxybenzoate
3.0 parts by weight glycerol
1.0 part by weight glycol
50.0 parts by weight water.

### Claim 15

A cosmetic hair treating composition which consists essentially of
0.1 g 2'-O-glucosyl-isovitexin
95 ml aqueous 61% ethanol
5 ml propylene glycol
0.1 g perfume
0.1 g colorant.