# US 5,346,886 A · Topical .alpha.-1-antitrypsin, non-aqueous lipid miscible, benzalkonium chloride compositions for treating skin

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- Number: US 5,346,886 A
- Document ID: US5346886A
- Status: Granted
- Kind: A
- Application number: 08/151,980
- Filed: 1993-11-15
- Granted: 1994-09-13
- Earliest claimed: 1993-11-15
- Inventors: John Lezdey; Allan Wachter
- Web page: https://patentgrep.com/patent/US5346886A

## CPC

- A61K 47/186: {Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide}
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 38/57: from animals; from humans {(A61K38/553, A61K38/556 take precedence)}
- A61P 17/00: Drugs for dermatological disorders
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The invention provides a pharmaceutical composition for the treatment of a mammal having a skin disease. The composition contains a serine protease inhibitor and an effective amount of a cationic quaternary ammonium salt at a concentration below the critical micelle concentration for increasing the penetration of the inhibitor in the skin. Additionally, these may be included an ethoxylated nonylphenol.

## Claims

### Claim 1

In a pharameceutical composition for the topical treatment of a mammal having a skin disease in which said composition contains an effective amount of .alpha.-1-antitrypsin and a non-aqueous lipid miscible carrier the improvement which comprises said composition containing an effective amount of benzalkonium chloride at an effective concentration for increasing the chemical stability and, penetration of said protease inhibitor in the skin.