# US 5,346,707 A · Food and feedstuff > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 5,346,707 A - Document ID: US5346707A - Status: Granted - Kind: A - Application number: 08/010,792 - Filed: 1993-01-29 - Granted: 1994-09-13 - Earliest claimed: 1988-12-02 - Inventors: Thomas Olin - Web page: https://patentgrep.com/patent/US5346707A ## CPC - A23K 20/142: Amino acids; Derivatives thereof - A23K 20/105: Aliphatic or alicyclic compounds - A23L 33/18: Peptides; Protein hydrolysates - A61P 1/16: for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics - A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00) - Y10S 426/807: Poultry or ruminant feed - A23K: FODDER - A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - Y10S: TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS ## Abstract The present invention relates to a process for reducing the excretion of nitrogen from humans and animals while maintaining formation of proteins, as well as a food and feedstuff for humans and animals comprising keto acids, whereby ingoing protein is replaced by alpha ketoglutaric acid; a combination of alpha keto glutaric acid and pyruvic acid; oxaloacetate or oxaloacetate in combination with alpha keto glutaric acid or pyruvate or another keto acid according to the formula R-CO-COOX, wherein R denotes a part of a non-essential amino acid and X denotes hydrogen, alkali metal, alkaline earth metal or organic base or non-toxic precursors or intermediates of these, whereby the keto acid (-s) is (are) present in an amount of 1 to 20% by weight, preferably 1-10% by weight of the protein dry matter present. ## Claims ### Claim 1 A parenteral nutrition composition for humans or animals comprising protein from said composition replaced by at least one keto acid of a non-essential amino acid according to the formula R--CO--COOX, wherein R is a part of a non-essential amino acid and X is selected from the group consisting of hydrogen, an alkali metal, an alkaline earth metal or an organic base, wherein said keto acid is present in an amount of 1 to 20% by weight, which composition is capable of substantially reducing nitrogen excretion. ### Claim 2 (depends on 1) The composition of claim 1, wherein said at least one keto acid is selected from the group consisting of alpha ketoglutaric acid, pyruvic acid and oxaloacetate. ### Claim 3 (depends on 1) The composition of claim 1 wherein said at least one keto acid is present in an amount of 1 to 10% by weight. ### Claim 4 (depends on 2) The composition of claim 2, wherein said keto acid is alpha ketoglutaric acid. ### Claim 5 (depends on 1) The composition according to claim 1, wherein said protein has been replaced by two keto acids which are mixed in a weight relationship of 25:75 to 75:25. ### Claim 6 (depends on 1) The composition of claim 1, wherein said protein has been replaced by two keto acids which are mixed in a weight relationship of 40:60 to 60: 40. ### Claim 7 (depends on 5) The composition of claim 5, wherein said keto acids are pyruvic acid and alpha ketoglutaric acid. ### Claim 8 (depends on 2) The composition of claim 2, wherein said at least one keto acid is oxaloacetate. ### Claim 9 (depends on 5) The composition of claim 5, wherein said keto acids are oxaloacetate and alpha ketoglutaric acid. ### Claim 10 (depends on 5) The composition of claim 5, wherein said keto acids are oxaloacetate and pyruvic acid. ### Claim 11 (depends on 1) The composition of claim 1, wherein said at least one keto acid is present in the form of an acid, a salt, or a mixture of an acid and a salt of an alkali metal, alkaline earth metal or organic base. ### Claim 12 (depends on 2) The composition of claim 2, wherein said at least one keto acid is present in the form of an acid, a salt, or a mixture of an acid and a salt of an alkali metal, alkaline earth metal or organic base. ### Claim 13 (depends on 3) The composition of claim 3, wherein said at least one keto acid is present in the form of an acid, a salt, or a mixture of an acid and a salt of an alkali metal, alkaline earth metal or organic base. ### Claim 14 (depends on 4) The composition of claim 4, wherein said at least one keto acid is present in the form of an acid, a salt, or a mixture of an acid and a salt of an alkali metal, alkaline earth metal or organic base. ### Claim 15 (depends on 5) The composition of claim 5, wherein said at least one keto acid is present in the form of an acid, a salt, or a mixture of an acid and a salt of an alkali metal, alkaline earth metal or organic base. ### Claim 16 (depends on 6) The composition of claim 6, wherein said at least one keto acid is present in the form of an acid, a salt, or a mixture of an acid and a salt of an alkali metal, alkaline earth metal or organic base. ### Claim 17 (depends on 7) The composition of claim 7, wherein said at least one keto acid is present in the form of an acid, a salt, or a mixture of an acid and a salt of an alkali metal, alkaline earth metal or organic base. ### Claim 18 (depends on 8) The composition of claim 8, wherein said at least one keto acid is present in the form of an acid, a salt, or a mixture of an acid and a salt of an alkali metal, alkaline earth metal or organic base. ### Claim 19 (depends on 9) The composition of claim 9, wherein said at least one keto acid is present in the form of an acid, a salt, or a mixture of an acid and a salt of an alkali metal, alkaline earth metal or organic base. ### Claim 20 (depends on 10) The composition of claim 10, wherein said at least one keto acid is present in the form of an acid, a salt, or a mixture of an acid and a salt of an alkali metal, alkaline earth metal or organic base.