# US 5,346,689 A · Method of performing angiography

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- Number: US 5,346,689 A
- Document ID: US5346689A
- Status: Granted
- Kind: A
- Application number: 08/111,294
- Filed: 1993-08-24
- Granted: 1994-09-13
- Earliest claimed: 1990-10-03
- Inventors: Gholam A. Peyman; Bahram Khoobehi
- Web page: https://patentgrep.com/patent/US5346689A

## CPC

- A61K 49/0041: {Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal (in vivo G01N)}
- A61K 49/006: {Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A method of performing angiography of the occular fundus of an eye of a patient includes the steps of injecting intravenously calcein into the patient in an effective amount immediately prior to angiography and performing angiography on the patient. The invention further discloses a method of performing photocoagulation therapy and/or photodynamic therapy and angiography of the ocular fundus of an eye of a patient which includes the steps of performing photocoagulation therapy, injecting intravenously calcein into the patient in an effective amount immediately prior to angiography, and performing angiography on the patient.

## Claims

### Claim 1

A method of performing photocoagulation therapy and angiography of the ocular fundus of an eye of a patient comprising the steps of:
performing photocoagulation therapy on the eye of the patient;
injecting intravenously a solution of purified calcein into the patient in an effective amount immediately prior to angiography; and
performing angiography on the patient.

### Claim 2 (depends on 1)

The method of claim 1 wherein the step of performing angiography comprises the step of using a fundus or video camera.

### Claim 3 (depends on 1)

The method of claim 1 wherein the calcein is purified by performing column chromatography.

### Claim 4 (depends on 1)

The method of claim 1 wherein the performing photocoagulation therapy step comprises using a laser.

### Claim 5 (depends on 4)

The method of claim 4 wherein the laser is an argon-blue green laser.

### Claim 6 (depends on 1)

The method of claim 1 wherein said effective amount is about 7 mg per kilogram of mammal body weight.

### Claim 7 (depends on 1)

The method of claim 1 wherein said calcein is in a water solution.