# US 5,346,621 A · Hollow fiber blood oxygenator > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 5,346,621 A - Document ID: US5346621A - Status: Granted - Kind: A - Application number: 08/063,996 - Filed: 1993-05-19 - Granted: 1994-09-13 - Earliest claimed: 1993-05-19 - Assignees: Avecor Cardiovascular, Inc. - Inventors: William S. Haworth; Robert W. Olsen; Mark S. Goodin; Larry E. Fuller - Web page: https://patentgrep.com/patent/US5346621A ## CPC - B01D 63/0233: {forming the bundle} - B01D 63/025: {Bobbin units} - B01D 2313/10: Specific supply elements - B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28) ## Abstract A radial flow hollow fiber blood oxygenator is provided. The oxygenator includes a hollow fiber bundle within an oxygenator chamber defined by a hollow core around which the hollow fibers are wound and an outer housing. A gas entry port is coupled to the interior of the fibers adjacent one end of the bundle and a gas outlet is coupled to the interior of the fibers at the opposite end of the bundle. A blood inlet to the core is provided adjacent one end of the bundle, and a blood outlet from the chamber is provided adjacent the same end of the bundle. The direction of blood flow through the chamber is generally radial and the oxygenator includes an inlet manifold and an outlet manifold. ## Claims ### Claim 1 A method of oxygenating blood in a generally vertically disposed, radial flow, hollow fiber blood oxygenator, said oxygenator including a hollow fiber bundle wound on a hollow core, said core having an interior lumen, radially spaced inlet and outlet manifolds surrounding the hollow fiber bundle, and means for providing blood only from the top of the interior lumen only to the inlet manifold, the oxygenator, bundle, core, lumen, and manifolds having corresponding top and bottom ends, said method comprising: introducing blood into the interior lumen at the bottom of the core at a pressure sufficient to induce blood flow to the top of the lumen; delivering blood from the top of the lumen, through the providing means only, and into the inlet manifold; providing a blood flow from the inlet manifold along the length thereof into and radially outward through the bundle and into the outlet manifold along the length thereof; and providing a blood outlet at the bottom of the outlet manifold for allowing blood to exit the oxygenator. ### Claim 2 A hollow fiber mass transfer device, comprising: a hollow fiber bundle wound around a supporting core, said core comprising a first end, second end and an axis extending from said first end to said second end, said hollow fiber bundle comprising hollow, gas permeable fibers each having a first end, a second end and a hollow interior, wherein the first ends of said fibers are adjacent the first end of said core and the second ends of said fibers are adjacent the second end of said core, said core further comprising: (i) an exterior surface having a plurality of ribs for supporting the fiber bundle and relieved regions disposed between the ribs for providing a first fluid to a radial inward region of the fiber bundle, and (ii) means for providing the first fluid to the relieved regions; an outer housing surrounding said hollow fiber bundle, said outer housing having collector means for collecting blood from a radially outward region of said hollow fiber bundle; first potting means for potting the first ends of said fibers and for sealing said fibers to said core and housing; second potting means for potting the second ends of said fibers and for sealing said fibers to said core and housing, wherein said first and second potting means, core and housing define an enclosed chamber; a second fluid inlet operatively connected to the interior of said fibers at one of said first ends and second ends and a second fluid outlet operatively connected to the interior of said fibers at the other of said first ends and second ends; and a first fluid inlet means operatively connected to the core and a first fluid outlet means operatively connected to the collector means, for compelling first fluid flowing between the first fluid inlet means and first fluid outlet means to flow substantially radially outward through the hollow fiber bundle. ### Claim 3 (depends on 2) A hollow fiber mass transfer device according to claim 2, wherein the length of the ribs is substantially equal to the distance between the first and second potting means. ### Claim 4 (depends on 3) A hollow fiber mass transfer device according to claim 3, wherein the length of the relieved regions is substantially equal to the distance between the first and second potting means less the length of the means for providing the first fluid to the relieved regions. ### Claim 5 (depends on 2) A hollow fiber mass transfer device according to claim 2, wherein said core further comprises a lumen having an open end in fluid communication with the means for providing the first fluid to the relieved regions, said means for providing the first fluid comprising a chamber at the open end of the lumen, said chamber having one or more windows open to the relieved regions for allowing the first fluid to flow from the lumen through the chamber and the one or more windows and into the relieved regions. ### Claim 6 (depends on 5) A hollow fiber mass transfer device according to claim 5, wherein there is a relieved region for each of the one or more windows and in discrete fluid communication therewith. ### Claim 7 (depends on 5) A hollow fiber mass transfer device according to claim 5, wherein the ratio of the cross-sectional area of the lumen adjacent to the open end thereof and the aggregate of the cross-sectional areas of the one or more windows is in the range of 0.5 to 1.5. ### Claim 8 (depends on 7) A hollow fiber mass transfer device according to claim 7, wherein the ratio is about 1. ### Claim 9 (depends on 5) A hollow fiber mass transfer device according to claim 5, wherein the ratio of the cross-sectional area of the aggregate of the relieved regions to the aggregate of the cross-sectional areas of the one or more windows is in the range of 0.7 to 1.7. ### Claim 10 (depends on 9) A hollow fiber mass transfer device according to claim 9, wherein the ratio is 1.5. ### Claim 11 (depends on 2) A hollow fiber mass transfer device according to claim 2, wherein the means for providing the first fluid to the relieved regions is adjacent to one of the first and second ends, and the first fluid outlet means is adjacent to the other of said ends. ### Claim 12 (depends on 2) A hollow fiber mass transfer device according to claim 2, wherein the length of the relieved regions is substantially the same as the length of the radially outward region of said hollow fiber bundle.