# US 5,345,944 A · Apparatus for medical diagnosis utilizing masking of fixation point

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 5,345,944 A
- Document ID: US5345944A
- Status: Granted
- Kind: A
- Application number: 08/031,976
- Filed: 1993-03-16
- Granted: 1994-09-13
- Earliest claimed: 1992-08-12
- Assignees: ATR Auditory and Visual Perception Research Laboratories
- Inventors: Hitoshi Hongo; Mitsuho Yamada; Kenya Uomori; Hiroshi Yoshimatsu; Keiichi Ueno; Mitsuru Fujii; Shinji Murakami; Jiro Miyazawa; Norihito Nakano; Ryo Fukatsu; Naohiko Takahata
- Web page: https://patentgrep.com/patent/US5345944A

## CPC

- A61B 3/113: for determining or recording eye movement
- G16H 15/00: ICT specially adapted for medical reports, e.g. generation or transmission thereof
- G16H 10/20: for electronic clinical trials or questionnaires
- G16H 40/63: for local operation
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA

## Abstract

When eye movement of a subject is detected by an eye movement detecting portion and head movement of the subject is detected by a head movement detecting portion, a line-of-sight calculating portion calculates the line-of-sight according to the detected outputs therefrom. A portion for generating an image to be presented generates an image as a task and presents the image to a task presenting portion. When a fixation point of the line-of-sight of the subject is determined by a fixation point determining portion, a mask image generated by a masking image generating portion is inserted to the task image by an image synthesizing portion, and it is presented at the task presenting portion. A portion for determining degree of advance of dementia determines degree of advance and possibility of Alzheimer's disease based on the particular movement of the line-of-sight of the subject at that time and on the percentage of correct answer to a prescribed task.

## Claims

### Claim 1

An apparatus for medical diagnosis employing fixation point masking, enabling diagnosis of a disease related to brain function by detecting line-of-sight of a subject, comprising:
eye movement detecting means for detecting eye movement of said subject;
line-of-sight calculating means responsive to a detection output from said eye movement detecting means for calculating actual movement of the line-of-sight of said subject;
image presenting means for presenting an image as a task for diagnosis to said subject;
image inserting means for inserting, when a fixation point is generated in spatial movement of the line-of-sight calculated by said line-of-sight calculating means, a desired masking image of an arbitrary size to the image presented by said image presenting means for an arbitrary time period, after the lapse of an arbitrary time period from fixation; and
determining means responsive to the movement of the line-of-sight calculated by said line-of-sight calculating means when said masking image is inserted to said presented image, determining whether or not the subject is suffering from a disease related to the brain function.

### Claim 2 (depends on 1)

The apparatus for medical diagnosis utilizing fixation point masking according to claim 1, further comprising:
head movement detecting means for detecting movement of the head of said subject; wherein
said line-of-sight detecting means includes means for calculating actual movement of the line-of-sight of said subject in response to a detection output from said head movement detecting portion and the detection output from said eye movement detecting means when said subject is gazing at said presented image.

### Claim 3 (depends on 1)

The apparatus for medical diagnosis utilizing fixation point masking according to claim 1, wherein
said determining means includes means for determining whether or not the subject is suffering from a disease related to brain function, by calculating fixation duration distribution, eye movement velocity distribution and locus of the line-of-sight in accordance with said calculated movement of the line-of-sight.

### Claim 4 (depends on 1)

The apparatus for medical diagnosis utilizing fixation point masking according to claim 1, wherein
said determining means includes means for determining whether or not the subject is suffering from a disease related to brain function based on the time at which said masking image is inserted to said presented image and on percentage of correct answer to said task.