# US 5,345,930 A · Method and apparatus for assisting expulsional movement of pulmonary secretions via supramaximal flows

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- Number: US 5,345,930 A
- Document ID: US5345930A
- Status: Granted
- Kind: A
- Application number: 07/832,895
- Filed: 1992-02-10
- Granted: 1994-09-13
- Earliest claimed: 1992-02-10
- Assignees: National Research Council Canada Intellectual Property Services Office
- Inventors: Pierre Cardinal; William E. Carscallen; Robert Ireland
- Web page: https://patentgrep.com/patent/US5345930A

## CPC

- A61M 16/0009: {with sub-atmospheric pressure, e.g. during expiration}
- A61M 16/0006: {with means for creating vibrations in patients' airways}
- A61M 16/024: {including calculation means, e.g. using a processor}
- A61M 16/0858: {Pressure sampling ports}
- A61M 2016/0042: {in the expiratory circuit}
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

There is described a non-invasive device designed to assist expectoration pulmonary secretions in humans, particularly in those whose natural exhalation and natural coughing ability are impaired. The device has a valve that opens fully in not more than 10 milliseconds, a pressure sensing means generating a signal indicative of a pressure in the upper part of the subject's respiratory tract, detecting means indicating the imminent collapse of the subject's respiratory tract or a part thereof, and control means opening or closing the valve respectively in response to the signals from the sensing means and the detecting means so as to create supramaximal flows in the respiratory tract in order to stimulate the movement of secretions towards the mouth of the subject. The valve opening/closing sequence is totally subject-controlled in accordance with a method of the invention which comprises the step of inducing supramaximal flows by determining a pressure threshold for the subject to be able to effect multiple openings and closings of the valve during a single respiratory cycle, determining a subject-specified parameter indicative of a substantial collapse of the subject's respiratory tract, and having the subject exhale against the valve to effect a rapid sequence of valve opening/closing cycles which cause the supramaximal flows and resulting movement of secretions towards the mouth of the subject.

## Claims

### Claim 1

An apparatus for assisting the movement of pulmonary secretions towards the outlet of a subject's respiratory tract by inducing supramaximal flows in a subject's respiratory tract during the subject's exhalation, the apparatus comprising means for moving the secretions toward the outlet of the subject's respiratory tract, said means including:
a) a valve having an opening time to a fully opened condition of not more than 10 milliseconds against a unidirectional expiratory flow of the subject, the valve having an inlet and an outlet, the inlet being adapted to be connected to the outlet of the respiratory tract of the subject;
b) pressure sensing means for generating a first signal indicative of a positive pressure in the upper part of the respiratory tract;
c) means for generating a second signal corresponding to a substantial collapse or near-collapse of the respiratory tract;
d) valve opening control means including means for establishing a predetermined pressure level and operative to open the valve in response to said first signal from said pressure sensing means indicating that the sensed pressure reaches or exceeds said predetermined level; and
e) valve closing control means operative to close the valve in response to said second signal corresponding to a substantial collapse or near-collapse of the respiratory tract, said opening of said valve inducing a cycle of events in the respiratory tract including a supramaximal expiratory flow and a resulting near-collapse of said tract followed by a closing of said valve, said cycle having a duration considerably shorter than an exhalation time of the subject, said valve opening and valve closing control means being operative, synchronously with said cycle, to repetitively open and close said valve a plurality of times during a single exhalation of the subject, said repetitive opening and closing of said valve thus creating a series of said supramaximal flows which is effective to move secretions towards the outlet of the subject's respiratory tract.

### Claim 2 (depends on 1)

The apparatus according to claim 1, further comprising a source of controlled reduced pressure, connected to the outlet of the valve.

### Claim 3 (depends on 2)

The apparatus according to claim 2, where the source of reduced pressure is a fixed volume/variable pressure chamber.

### Claim 4 (depends on 3)

The apparatus according to claim 3 wherein said fixed volume/variable pressure chamber has a preset volume and vacuum level selected so that a maximum volume of gas drawn by the chamber does not exceed the sum of the subject's tidal lung volume and expiratory reserve lung volume.

### Claim 5 (depends on 2)

The apparatus according to claim 2, wherein the source of reduced pressure is a substantially uniform vacuum source.

### Claim 6

A method of assisting the movement of pulmonary secretions towards the outlet of a subject's respiratory tract by inducing supramaximal flows in the respiratory tract, comprising the steps of:
a) determining a pressure threshold which the subject is comfortably capable of reaching in the respiratory tract through an expiratory cycle when breathing against an initially closed valve which opens upon the pressure in the upper respiratory tract reaching the pressure threshold;
b) determining a subject-specific parameter indicative of a substantial collapse of the subject's respiratory tract to a degree where the respiratory flow is substantially stopped or obstructed for closing the valve when the parameter is reached during the expiratory cycle;
c) choosing a valve opening pressure threshold and a valve closing parameter for operation of the valve wherein the subject can effect multiple openings and closings of said valve during a single expiratory cycle; and
d) having a subject repeatedly inhale freely and then exhale against an initially closed valve which opens in not more than 10 milliseconds upon the pressure in the upper respiratory tract reaching the chosen pressure threshold and closes in response to the chosen valve closing parameter being met, the opening and closing of said valve generating supramaximal flows in the respiratory tract of the subject, said flows being effective to move pulmonary secretions towards the outlet of the subject's respiratory tract.

### Claim 7 (depends on 6)

The method according to claim 6 wherein the parameter is selected to correspond to a period of time in which at least a part of the subject's respiratory tract collapses upon forced expiration thereby substantially obstructing the expiratory flow.

### Claim 8 (depends on 6)

The method according to claim 6 wherein the parameter is selected to correspond to the expiratory flow rate.

### Claim 9 (depends on 6)

The method according to claim 6 wherein the duration of full closure of the valve is selected to be not more than 10 milliseconds.