1,2 diarylcyclopentenyl compounds for the treatment of inflammation

A compound of Formula III ##STR42## wherein each of R.sup.1 and R.sup.2 is independently selected from alkyl, hydrido, hydroxyalkyl, halo, haloalkyl, alkylcarboxyl and carboxyl;

• wherein R.sup.5 is alkylsulfonyl or sulfamyl;
• wherein R.sup.8 is selected from hydrido, alkyl and halo;
• and
• wherein R.sup.10 is selected from hydrido, malo, alkyl, alkylthio, cyano, haloalkyl, alkoxy, hydroxyalkyl and alkoxyalkyl;
• or a pharmaceutically-acceptable salt thereof.

A pharmaceutical composition comprising a therapeutically-effective amount of an anti-inflammatory compound and a pharmaceutically-acceptable carrier or diluent, said compound selected from compounds of Formula II ##STR43## wherein each of R.sup.1 and R.sup.2 is independently selected from alkyl, hydrido, hydroxyalkyl, halo, haloalkyl, alkylcarboxyl and carboxyl;

• wherein R.sup.5 is alkylsulfonyl or sulfamyl;
• and
• wherein each of R.sup.3, R.sup.4 and R.sup.6 through R.sup.12 is independently selected from hydrido, halo, alkyl, alkylthio, cyano, haloalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, alkylsulfonyl and sulfamyl;
• or a pharmaceutically suitable salt thereof.

A method of treating inflammation or an inflammation-associated disorder, said method comprising administering to a subject having said inflammation or said inflammation-associated disorder, a therapeutically-effective amount of a compound of Formula II ##STR44## wherein each of R.sup.1 and R.sup.2 is independently selected from alkyl, hydrido, hydroxyalkyl, halo, haloalkyl, alkylcarboxyl and carboxyl;

• wherein R.sup.5 is alkylsulfonyl or sulfamyl;
• and
• wherein each of R.sup.3, R.sup.4 and R.sup.6 through R.sup.12 is independently selected from hydrido, halo, alkyl, alkylthio, cyano, haloalkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, alkylsulfonyl and sulfamyl;
• or a pharmaceutically suitable salt thereof.