# US 5,344,947 A · Optically active derivatives of glycidol

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 5,344,947 A
- Document ID: US5344947A
- Status: Granted
- Kind: A
- Application number: 08/005,938
- Filed: 1993-01-15
- Granted: 1994-09-06
- Earliest claimed: 1986-10-01
- Assignees: Massachusetts Institute of Technology
- Inventors: Karl B. Sharpless; Janice M Klunder
- Web page: https://patentgrep.com/patent/US5344947A

## CPC

- C07D 303/16: by esterified hydroxyl radicals
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

Optically active derivatives of glycidol are disclosed. These compounds, (2S) and (2R) glycidyl tosylate and (2S) and (2R) glycidyl 4-chloro-3-nitrobenzenesulfonate can be readily crystallized to high enantiomeric purity. Their use in other synthesis reactions is also described.

## Claims

### Claim 1

A compound of the formula ##STR5## having an enantiomeric purity of at least about 90% e.e.

### Claim 2 (depends on 1)

The compound of claim 1 purified to at least about 94.0% e.e.

### Claim 3 (depends on 1)

The compound of claim 1 purified to at least about 98.0% e.e.

### Claim 4

A compound of the formula ##STR6## having an enantiomeric purity of at least about 90% e.e.

### Claim 5 (depends on 4)

The compound of claim 4 purified to at least about 94.0% e.e.

### Claim 6 (depends on 4)

The compound of claim 4 purified to at least about 98.0% e.e.