# US 5,344,938 A · Indole 3-carboxylic acid derivatives

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- Number: US 5,344,938 A
- Document ID: US5344938A
- Status: Granted
- Kind: A
- Application number: 08/041,180
- Filed: 1993-04-01
- Granted: 1994-09-06
- Earliest claimed: 1992-04-07
- Assignees: Kyowa Hakko Kogyo Co., Ltd.
- Inventors: Masaji Kasai; Hitoshi Arai; Hiroshi Nishikawa; Takehiro Ogasa; Masahiko Kinugawa; Shinji Tomioka
- Web page: https://patentgrep.com/patent/US5344938A

## CPC

- C07D 209/42: Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A61P 35/00: Antineoplastic agents
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

An indole derivative represented by formula (I): ##STR1## wherein R.sup.1 is a lower alkoxymethyl group or a formyl group, R.sup.2 is a lower alkyl group, R.sup.3 is a hydrogen atom or a lower alkyl group and R.sup.4 is a hydrogen atom or a lower alkyl group, which is useful as an intermediate for the synthesis of a compound, 5-aziridino-3-hydroxymethyl-l-methyl-2- (1H-indole-4,7-dione)prop-.beta.-ene-.alpha.-ol, which has antitumor activity.

## Claims

### Claim 1

A compound represented by formula (I): ##STR11## wherein R.sup.2 is a lower alkyl group, R.sup.3 is a lower alkyl group and R.sup.4 is a lower alkyl group.

### Claim 2 (depends on 1)

The compound according to claim 1, wherein R.sup.2 is a methyl group R.sup.3 is a methyl group and R.sup.4 is a methyl group.