Phenothiazine derivatives, their production and use
AssigneeTakeda Chemical Industries, Ltd.
InventorsHirotomo Masuya, Hiroshi Shimadzu, Toshio Miyawaki, Marvin A. Motsenbocker
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Abstract
There is disclosed a novel phenothiazine derivative of the general formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and are a C.sub.1-6 alkyl group and at least one of them has as a substituent a group which can react with amino group, thiol group or carboxyl group, and X.sup.- is a counter ion of the phenazathionium. Their production and the intermediates used in the production are also disclosed. The compound (I) is a derivative of methylene blue and is applicable to photodynamic therapy of cancer or immunoassays utilizing chemiluminescence.
Claims10
A phenothiazine derivative of the formula (I):
- ##STR16## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and are respectively a C.sub.1-6 alkyl group, at least one of which has as a substituent a group which can react with amino group, thiol group or carboxyl group, and X' is a counter ion of the phenazathionium.
A phenothiazine derivative of the formula (II):
- ##STR17## wherein at least one of R.sub.1 ', R.sub.2 ', R.sub.3 ' and R.sub.4 ' is a group of the formula:
- --(CH.sub.2)m--CO--Y, the others are C.sub.1-6 alkyl group, Y is a lower alkoxy group having 1 to 4 carbon atoms, an aralkyloxy group or a 1-phenoxy-ethoxy group, m is an integer of 1 to 6 and X.sup.- is a counter ion of the phenazathionium.
Dependencies are inferred from the claim text.