Compound and use of the same as medicine
AssigneeTsumura & Co.
InventorsAkihide Koda, Koji Waragai, Yutaka Ono, Hideyuki Ozawa, Hideki Kawamura, Masao Maruno, Takeshi Wakamatsu
Life of this patent
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Abstract
Disclosed herein is a specific cinnamic acid derivative such as methyl 4-(4-acetoxy-3-methoxycinnamanide)-1-cyclohexanecarboxylate, or a pharmaceutically acceptable salt thereof. These compounds are useful as IV-type allergic reaction-suppressive drugs.
Claims7
A compound represented by formula (I) shown below or a pharmaceutically acceptable salt thereof:
- ##STR6## where L represents --(CH.dbd.CH).sub.k -- or --(CH.sub.2)k--;
- j represents an integer of 1 to 6;
- k represents an integer of 0 to 5;
- and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are either identical or different, and each represents a hydrogen atom, an amino group, an acylamino group, a dialkylamino group in which each alkyl moiety has 1 to 5 carbon atoms, a halogen atom, a hydroxyl group, an acetoxy group, an alkoxy group having 1 to 3 carbon atoms, a trifluoromethyl group, a nitro group, tetrahydropyranyloxy group, or a benzyloxy group.
A compound represented by formula II shown below, or a pharmaceutically acceptable salt thereof:
- ##STR7## where L represents --(CH.dbd.CH).sub.k -- or --(CH.sub.2)k--;
- each k represents an integer of 1 to 5;
- R.sub.5, R.sub.6 and R.sub.7 are either identical or different, and each represents a hydrogen atom, a hydroxyl group, an acetoxy group, an amino acid ester group in which the amino moiety may be protected by a protective group, an alkoxy group having 1 to 3 carbon atoms, or --O--(CH.sub.2)j--Y.sub.1 ;
- j represents an integer of 1 to 6;
- and Y1 is a halogen atom, an amino group, an amino group substituted with 1 or 2 thioethanol groups, an amino group substituted with 1 or 2 allyl groups, a monoalkylamino group having 1 to 10 carbon atoms, a dialylamino group in which each alkyl moiety has 1 to 10 carbon atoms, an imidazole group substituted with 1 to 3 substituent groups, a benzimidazole group substituted with 1 to 3 substituent groups, a diazole group, a triazole group, a tetrazole group, a piperidine group, a piperidinopiperidine group, an isonipecotic acid group or an ester thereof with an alkyl group having 1 to 5 carbon atoms, a thiazolidine group, a pyrrolidine group, a morpholine group, a 4-methylpiperazine group, a carboxyl group, a carboxylic acid alkylester group in which the alkyl moiety has 1 to 5 carbon atoms or a carboxamide group.
A VI-type allergy suppressive drug containing, as an effective component, a compound represented by formula (I) or a pharmaceutical, acceptable salt thereof:
- ##STR8## where L represents --(CH.dbd.CH).sub.k -- or --(CH.sub.2).sub.k --;
- j represents an integer of 1 to 6;
- k represents an integer of 0 to 5;
- and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are either identical or different, and each represents a hydrogen atom, an amino group, an acylamino group, a dialkylamino group in which each alkyl moiety has 1 to 5 carbon atoms, a halogen atom, a hydroxyl group, an acefoxy group, an alkoxy group having 1 to 3 carbon atoms, a trifluoromethyl group, a nitro group, tetrahydropyranyloxy group, or a benzyloxy group;
A IV-type allergy suppressive drug containing, a IV-type allergy suppressive amount of a compound represented by formula (II) or a pharmaceutical acceptable salt thereof:
- ##STR9## where L represents --(CH.dbd.CH).sub.k -- or --(CH.sub.2).sub.k --;
- each k represents an integer of 0 to 5;
- identical or different, and each represents a hydrogen atom, a hydroxyl group, an acetoxy group, an amino acid ester group in which the amino moiety may be protected by a protective group, an alkoxy group having 1 to 3 carbon atoms, or --O--(CH.sub.2).sub.j --Y.sub.1;
- j represents an integer of 1 to 6;
- and Y1 is a halogen atom, an amino group, an amino group substituted with 1 or 2 thioethanol groups, an amino group substituted with 1 or 2 allyl groups, a monoalkylamino group having 1 to 10 carbon atoms, a dialylamino group in which each alkyl moiety has 1 to 10 carbon atoms, an imidazole group substituted with 1 to 3 substituent groups, a benzimidazole group substituted with 1 to 3 substituent groups, a diazole group, a triazole group, a tetrazole group, a piperidine group, a piperidinopiperidine group, an isonipecotic acid group or an ester thereof with an alkyl group having 1 to 5 carbon atoms, a thiazolidine group, a pyrrolidine group, a morpholine group, a 4-methylpiperazine group, a carboxyl group, a carboxylic acid alkylester group in which the alkyl moiety has 1 to 5 carbon atoms or a carboxamide group.
Dependencies are inferred from the claim text.