# US 5,344,840 A · 4-substituted imidazole derivatives useful in perioperative care

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- Number: US 5,344,840 A
- Document ID: US5344840A
- Status: Granted
- Kind: A
- Application number: 08/003,681
- Filed: 1993-01-13
- Granted: 1994-09-06
- Earliest claimed: 1988-02-29
- Assignees: Orion-yhtyma Oy
- Inventors: Mervyn Maze; Mika Scheinin
- Web page: https://patentgrep.com/patent/US5344840A

## CPC

- A61K 31/415: 1,2-Diazoles
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, known as medetomidine, and in particular its d-enantiomer and salts thereof are useful in perioperative care, in particular in reducing the amount of anaesthetic it is necessary to administer.

## Claims

### Claim 1

A method of perioperative treatment of mammals to reduce the responses of the autonomic nervous system to stressful stimuli during an operation by administering to said mammal in whom such reduction is desired an effective amount of dextro 4-[1-(2,3-dimethylpheny)-ethyl] -1H-imidazole or a non-toxic pharmaceutically acceptable salt thereof substantially in the absence of the laevo form of said compound.

### Claim 2 (depends on 1)

A method according to claim 1 wherein the compound is administered as anxiolytic analgesic premedication prior to an operation with or without the administration of an amount of anaesthetic sufficient to achieve a desired level of local or general anaesthesia.

### Claim 3 (depends on 1)

A method according to claim 1 wherein the compound is administered preoperatively as sedative analgesic to potentiate the effect of an anaesthetic and thus to reduce the amount of anaesthetic required to achieve a desired level of anaesthesia.