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AssigneesThe Board of Supervisors of Louisiana University and Agricultural and Mechanical College, Ergo Science Incorporated
InventorsAnthony H. Cincotta, Albert H. Meier
Estimating the term…
A process for the long term modification and regulation of lipid and glucose metabolism--generally to reduce obesity, insulin resistance, and hyperinsulinemia or hyperglycemia, or both (these being the hallmarks of noninsulin dependent, or Type II diabetes)--by administration to a vertebrate, animal or human, of a dopamine agonist and a prolactin stimulator. The dopamine agonist and prolactin stimulator are administered in daily dosages, respectively, at a time of day dependent on the normal circadian rhythm of fat and lean members of a similar species. Decreases in body fat deposits result by treatment of an obese species on a daily timed sequence based on circadian rhythms of the peak prolactin, or peak prolactin and peak glucocorticosteroid, blood level established for lean insulin sensitive members of a similar species. The dopamine agonist is administered at the time of, or just after the time of peak plasma prolactin concentration found in lean animals of the same species and the prolactin stimulator is administered at a time just before the plasma prolactin rhythm reaches its peak in lean animals. Insulin resistance, and hyperinsulinemia or hyperglycemia, or both, can also be controlled in humans on a long term basis by treatment corresponding to that of the treatment for obesity. The short term daily injections reset hormonal timing in the neural centers of the brain to produce long term effects.
A method for modifying and regulating at least one of the lipid and glucose metabolism in a vertebrate animal or human subject in need of such treatment comprising:
A method for modifying and resetting the neutral phase oscillations of the brain which control prolactin levels in the bloodstream of a vertebrate animal or human subject, the method comprising administering a dopamine agonist and a prolactin stimulator to said subject on a daily basis at different times predetermined to produce a change of the plasma prolactin rhythm of said subject to mimic that of a lean insulin-sensitive subject, said administrations continuing for periods of time sufficient to increase the cellular sensitivity of the subject to insulin and reduce hyperglycemia, said increase and reduction persisting after cessation of said administrations.
A method for modifying and resetting the neutral phase oscillations of both the prolactin and glucocorticosteroid rhythms in an obese insulin resistant vertebrate animal or human subject, which comprises
A method for modifying lipid and glucose metabolism in a lean human in need of such treatment the method comprising:
A method for modifying and regulating at least one of lipid and glucose metabolism in a human in need of such treatment, said method comprising administering bromocriptine to said human on a timed daily basis at a first predetermined time of day in a first dosage amount sufficient to reduce hyperglycemia and hyperinsulinemia and to reduce hormonal prolactin level in the blood of said human and additionally administering metoclopramide to said human on a timed daily basis at a second predetermined time of day in a second dosage amount sufficient to increase normal prolactin level in the blood of said human;
A method for modifying and regulating lipid and glucose metabolism in a vertebrate animal or human subject in need of such treatment comprising administering daily to said subject at a predetermined time of day a prolactin stimulator wherein said predetermined time of day is shortly before the daily peak of the prolactin level of a lean healthy member of the same species as said subject, in an amount sufficient to increase the normal prolactin level in the blood of said subject to cause said subject's daily prolactin level to peak at about the same time as the daily prolactin level of said lean healthy member of the same species.
A method for treating Type II diabetes in a vertebrate animal or human subject in need of such treatment comprising
Dependencies are inferred from the claim text.