# US 5,344,824 A · Method for reducing insulin secretion > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 5,344,824 A - Document ID: US5344824A - Status: Granted - Kind: A - Application number: 07/933,909 - Filed: 1992-08-27 - Granted: 1994-09-06 - Earliest claimed: 1990-02-02 - Assignees: Matsutani Chemical Industries Co., Ltd. - Inventors: Kazuhiro Ohkuma; Shigeru Wakabayashi; Yoshimi Mochizuki; Mitsuko Satouchi - Web page: https://patentgrep.com/patent/US5344824A ## CPC - A23L 33/21: Addition of substantially indigestible substances, e.g. dietary fibres - A23L 29/35: {Degradation products of starch, e.g. hydrolysates, dextrins; Enzymatically modified starches} - A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B) ## Abstract A food composite for saving insulin secretion comprising a refined product of pyrodextrin obtained as an active ingredient through a process of decomposing starch or starch hydrolyzate by heating in the presence of an acid or without acid. ## Claims ### Claim 1 A method for reducing insulin secretion without negatively affecting/influencing blood glucose levels in an animal which comprises the steps of: (a) providing a pyrodextrin hydrolysate which is obtained by heating starch in the presence of a mineral acid and in the presence of water in an amount of not more than about 5% based on the weight of the starch to prepare pyrodextrin, hydrolyzing the pyrodextrin with alpha-amylase and refining the hydrolyzed pyrodextrin; and (b) orally administering an effective amount of the pyro-dextrin hydrolysate to the animal. ### Claim 2 (depends on 1) The method of claim 1, wherein said pyrodextrin hydrolysate contains 1.fwdarw.4, 1.fwdarw.6, 1.fwdarw.2 and 1.fwdarw.3 glucosidic linkages and some of the reducing terminal groups of said pyrodextrin hydrolysate are 1.fwdarw.6 anhydroglucose groups. ### Claim 3 (depends on 1) The method of claim 1, wherein said pyrodextrin hydrolysate is obtained by heating said starch in the presence of hydrochloric acid in an amount of 0.01 to 0.1% by weight based on the weight of said starch at about 130.degree. C. to 220.degree. C. for 1 to 5 hours to prepare pyrodextrin, dissolving the pyrodextrin in water in an amount of 30 to 50% by weight based on the weight of the solution, adjusting the pH of the solution to pH 5.5 to 6.5, treating the solution with alpha-amylase in an amount of 0.05 to 0.2% by weight based on the weight of the pyrodextrin at 85.degree. C. to 100.degree. C. for 0.5 to 2 hours, and refining the hydrolyzed pyrodextrin. ### Claim 4 (depends on 1) The method of claim 1, wherein said animal is a human being. ### Claim 5 (depends on 4) The method of claim 4 wherein said pyrodextrin hydrolysate is administered in the form of food containing the same. ### Claim 6 A method for reducing insulin secretion without negatively affecting/influencing blood glucose levels in an animal which comprises the steps of: (a) providing a pyrodextrin hydrolysate which is obtained by heating starch in the presence of a mineral acid and in the presence of water in an amount of not more than about 5% based on the weight of the starch to prepare pyrodextrin, hydrolyzing the pyrodextrin with alpha-amylase and then with glucoamylase, and subjecting the hydrolyzed dextrin to ion exchange resin chromatography to refine the hydrolyzed pyrodextrin; and (b) orally administering an effective amount of the pyro-dextrin hydrolysate to the animal. ### Claim 7 (depends on 6) The method of claim 6, wherein said pyrodextrin hydrolysate contains 1.fwdarw.4, 1.fwdarw.6, 1.fwdarw.2 and 1.fwdarw.3 linkages and some of the reducing terminal groups of said pyrodextrin hydrolysate are 1.fwdarw.6 anhydroglucose groups. ### Claim 8 (depends on 6) The method of claim 6, wherein said pyrodextrin hydrolysate is obtained by heating said starch in the presence of hydrochloric acid in an amount of 0.01 to 0.1% by weight based on the weight of said starch at about 130.degree. C. to 220.degree. C. for 1 to 5 hours to prepare pyrodextrin, dissolving the pyrodextrin in water in an amount of 30 to 50% by weight based on the weight of the solution, adjusting the pH of the solution to pH 5.5 to 6.5, treating the solution with alpha-amylase in an amount of 0.05 to 0.2% by weight based on the weight of the pyrodextrin at 85.degree. C. to 100.degree. C. for 0.5 to 2 hours, treating the solution with glucoamylase in an amount of 0.05 to 0.2% by weight based on the weight of the pyrodextrin at about 55.degree. C. for 24 to 48 hours, refining the hydrolyzed pyrodextrin and subjecting the hydrolyzed and refined pyrodextrin to ion exchange resin chromatography to separate said pyrodextrin hydrolysate. ### Claim 9 (depends on 8) The method of claim 8, wherein said ion exchange resin is an alkaline metal or alkaline earth metal strongly acidic ion exchange resin. ### Claim 10 (depends on 6) The method of claim 6, wherein said animal is a human being. ### Claim 11 (depends on 10) The method of claim 10, wherein said pyrodextrin hydrolysate is administered in the form of food containing the same.