# US 5,344,823 A · Antitumor antibiotic BMY-41219

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- Number: US 5,344,823 A
- Document ID: US5344823A
- Status: Granted
- Kind: A
- Application number: 07/830,969
- Filed: 1992-02-06
- Granted: 1994-09-06
- Earliest claimed: 1990-03-06
- Assignees: Bristol-Myers Squibb Company
- Inventors: Kin S. Lam; Leonard A. McDonald; Jacqueline Mattei; Salvatore Forenza; James A. Matson
- Web page: https://patentgrep.com/patent/US5344823A

## CPC

- A61K 31/70: Carbohydrates; Sugars; Derivatives thereof (sorbitol A61K31/047)
- C07H 19/044: Pyrrole radicals
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C07H: SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS (derivatives of aldonic or saccharic acids C07C, C07D; aldonic acids, saccharic acids C07C59/105, C07C59/285; cyanohydrins C07C255/16; glycals C07D; compounds of unknown constitution C07G; polysaccharides, derivatives thereof C08B; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; sugar industry C13)

## Abstract

A new antitumor antibiotic designated BMY-41219 is produced by fermentation of Saccharothrix aerocolonigenes ATCC 39243. The BMY-41219 antibiotic exhibits antitumor activity.

## Claims

### Claim 1

A process for producing the compound of the formula: ##STR5## or a pharmaceutically acceptable acid addition salt thereof, which comprises cultivating a rebeccamycin-producing strain of Saccharothrix aerocolonigenes in an aqueous nutrient medium in the presence of tryptophan, until a substantial amount of said compound is produced by said organism in said culture medium and recovering said compound from the culture medium in a substantially pure form.

### Claim 2 (depends on 1)

The process of claim 1 wherein the rebeccamycin-producing strain is Saccharothrix aerocolonigenes ATCC 39243.

### Claim 3 (depends on 1)

A method for therapeutically treating a mammalian host affected by a tumor sensitive to P388 leukemia which comprises administering to said host an effective tumor-inhibiting amount of the compound as defined in claim 1.