# US 5,344,820 A · Infection protectant

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- Number: US 5,344,820 A
- Document ID: US5344820A
- Status: Granted
- Kind: A
- Application number: 07/879,421
- Filed: 1992-05-07
- Granted: 1994-09-06
- Earliest claimed: 1987-05-15
- Assignees: Snow Brand Milk Products Co., Ltd.
- Inventors: Shunichi Dosako; Hiroko Kusano; Eiki Deya; Tadashi Idota
- Web page: https://patentgrep.com/patent/US5344820A

## CPC

- C07K 14/4732: {Casein (in foodstuffs A23J)}
- A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00)
- Y10S 530/832: Milk; colostrum
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- Y10S: TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

## Abstract

Disclosed herein is an infection protectant which is excellent in infection protective effects and is also safe. .kappa.-Casein, a sialic-acid-conjugated protein derived from cow milk, and a glycomacropeptide derived from .kappa.-casein, each of which is useful as an active ingredient in this invention, have been found to be effective for the prevention of adhesion of E. coli on cells and also for the inhibition of transformation of lymphocytes by EBV and also to have strong HI activity against virus. The infection protectant of this invention is hence believed to exhibit marked effects for the prevention of occurrence of infectious diarrhea, for mass protection against spreading of influenza, and also against canceration of lymphocytes. Since the active ingredient of the infection protectant is a substance derived from cow milk, it is free of any problem from the viewpoint of safety. Moreover, it is absolutely tasteless and odorless. It can therefore be added to foods for its application.

## Claims

### Claim 1

A method for protection against gastrointestinal bacteria, Epstein-Barr and influenza viruses that comprises administering an effective amount of an isolated and purified sialic acid-conjugated peptide to a patient in need thereof, wherein the sialic acid-conjugated peptide is a glycomacropeptide obtained by reacting rennet or pesin with .kappa.-casein, cow milk, reconstituted milk or casein at pH 5.5-5.6.

### Claim 2 (depends on 1)

The method of claim 1, wherein the sialic acid-conjugated peptide is a glycomacropeptide obtained by reacting rennet with .kappa.-casein at pH 5.5-5.6.