# US 5,344,655 A · External application base or auxiliary agent and external application composition for human being or animal containing the same

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- Number: US 5,344,655 A
- Document ID: US5344655A
- Status: Granted
- Kind: A
- Application number: 08/032,100
- Filed: 1993-03-17
- Granted: 1994-09-06
- Earliest claimed: 1990-03-12
- Assignees: Showa Denko K.K.
- Inventors: Yasuyuki Sakai; Noriyuki Suzuki; Tetsuo Kudo; Kuniomi Marumo; Toshiyuki Aizawa; Kunio Imamura; Shuichi Sugita; Kazuo Kanbayashi
- Web page: https://patentgrep.com/patent/US5344655A

## CPC

- A61K 9/7053: {obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene}
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/7023: {Transdermal patches and similar drug-containing composite devices, e.g. cataplasms (galenical aspects of iontophoretic devices A61K9/0009; microneedle arrays A61K9/0021; buccal patches A61K9/006)}
- A61K 9/7061: {Polyacrylates}
- A61K 47/32: Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A (co)polymer suitable for bases or auxiliary agents for external application (for example, hydrophilic gels, adhesives, thickeners or excipients) to be coated or plastered onto the skin or mucosa of a human being or animal, such as ointment agents (ointment, hydrogel, jelly or cream), plastering agents (molded poultice, tape agent or plaster agent), sticky bandages (sticky bandage, strap, wound strap, surgical tape, taping material, supporter), and to preparations for external application containing same.

## Claims

### Claim 1

A base or an auxiliary agent for external application for a human being or animal, comprising a polymer or copolymer of N-vinylacetamide having a structure containing 50 to 100 mole % of the repeating unit represented by the formula (I) and 0 to 50 mole % of at least one kind of the repeating units represented by the formula (II): ##STR24## wherein R.sup.1 represents H, CH.sub.3, C.sub.6 H.sub.5, or COOM, wherein M represents H or an alkali metal; R.sup.2 represents H, CH.sub.3, COOM; and X represents COOM; when R.sup.1 and X are COOM, the formula (II) also may have a cyclic acid anhydride structure.

### Claim 2 (depends on 1)

A base or an auxiliary agent for external application for a human being or animal according to claim 1, wherein said polymer contains, as the essential component, a crosslinked polymer having a structure crosslinked: (1) by copolymerization in the presence of a crosslinking agent during the polymerization reaction for forming said polymer, or (2) by crosslinking with a polyfunctional compound or a polyvalent metal ion after a polymerization reaction.

### Claim 3 (depends on 1)

A base or auxiliary agent for external application according to claim 1, wherein the polymer or copolymer of N-vinylacetamide has a viscosity of 5 cps or more, at 30.degree. C. and 20 rpm, in a 0.2% aqueous solution, as measured by a Brookfield type viscometer.