# US 5,344,651 A · Cyproterone acetate thioacetate

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 5,344,651 A
- Document ID: US5344651A
- Status: Granted
- Kind: A
- Application number: 08/096,086
- Filed: 1993-07-23
- Granted: 1994-09-06
- Earliest claimed: 1993-07-23
- Assignees: The Procter & Gamble Company
- Inventors: Richard J. Schwen; Mark R. Sine; Raphael Warren
- Web page: https://patentgrep.com/patent/US5344651A

## CPC

- A61K 8/63: Steroids; Derivatives thereof
- A61K 31/56: Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K 31/57: substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61Q 5/00: Preparations for care of the hair
- A61Q 7/00: Preparations for affecting hair growth
- A61Q 19/00: Preparations for care of the skin
- A61Q 19/008: {Preparations for oily skin}
- C07J 53/004: {3 membered carbocyclic rings}
- A61K 2800/91: Injection
- A61Q 5/02: Preparations for cleaning the hair
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- C07J: STEROIDS (seco-steroids C07C)

## Abstract

The present invention relates to the compound cyproterone acetate thioacetate (CATA) and compositions comprising CATA. The present invention further relates to methods of treating acne and/or sebaceous gland activity comprising topical application of CATA. The present invention additionally relates to methods of regulating hair growth comprising application of compositions comprising CATA.

## Claims

### Claim 1

A compound having the structure ##STR2##

### Claim 2

A pad for topical delivery of an active comprising:
a. from about 50% to about 75% by weight of one or more layers of nonwoven fabric material; and
b. from about 25% to about 50% by weight of a liquid composition, deliverable from the nonwoven fabric material, comprising from about 0.01% to about 10% of a compound having the structure: ##STR3##

### Claim 3

A fluid dispensing device comprising:
a. a fluid container with a mouth;
b. a soft, porous-tipped applicator at an end of the fluid container;
c. a means for holding the applicator in the mouth of the container; and
d. a liquid composition, deliverable from the fluid container through the applicator onto the skin, comprising from about 0.01% to about 10% of a compound having the structure ##STR4##

### Claim 4

A composition comprising:
a. a safe and effective amount of a compound having the structure ##STR5## b. a pharmaceutically-acceptable or cosmetically-acceptable carrier.

### Claim 5 (depends on 4)

The composition of claim 4, wherein the carrier is a topical carrier.

### Claim 6 (depends on 5)

The composition of claim 5, wherein the composition comprises from about 0.001% to about 5% of the compound.

### Claim 7 (depends on 4)

The composition of claim 4, wherein the carrier is an injectable carrier.

### Claim 8 (depends on 4, 5, 6)

The composition of any one of claims 4, 5 or 6, wherein the composition additionally comprises an ache treating agent selected from the group consisting of anti-inflammatory agent, retinoid, antimicrobial agent, antiandrogen and comedolytic agent.

### Claim 9 (depends on 4, 5, 6)

A method of treating acne comprising topical application of the composition of any one of claims 4, 5 or 6.

### Claim 10 (depends on 4, 5, 6)

A method of treating excessive sebaceous gland activity in mammalian skin and scalp comprising topical application of the composition of any one of claims 4, 5 or 6.

### Claim 11 (depends on 4, 5, 6, 7)

A method of regulating hair growth comprising administration of the composition of any one of claims 4, 5, 6 or 7.