# US 5,344,455 A · Graft polymer articles having bioactive surfaces

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- Number: US 5,344,455 A
- Document ID: US5344455A
- Status: Granted
- Kind: A
- Application number: 07/969,692
- Filed: 1992-10-30
- Granted: 1994-09-06
- Earliest claimed: 1992-10-30
- Assignees: Medtronic, Inc.
- Inventors: James R. Keogh; Christopher M. Hobot; John W. Eaton; Allan H. Jevne; Matthew A. Bergan
- Web page: https://patentgrep.com/patent/US5344455A

## CPC

- A61L 29/16: Biologically active materials, e.g. therapeutic substances {(A61L29/048 takes precedence)}
- A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)}
- A61L 33/0029: {using an intermediate layer of polymer}
- A61L 2300/104: Silver, e.g. silver sulfadiazine
- A61L 2300/206: Biguanides, e.g. chlorohexidine
- A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents
- A61L 2300/406: Antibiotics
- A61L 2300/414: Growth factors
- A61L 2300/42: Anti-thrombotic agents, anticoagulants, anti-platelet agents
- A61L 2300/442: Colorants, dyes
- A61L 2300/602: Type of release, e.g. controlled, sustained, slow
- Y10S 623/901: Method of manufacturing prosthetic device
- Y10S 623/921: Blood vessel
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- Y10S: TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

## Abstract

Articles comprised of bioactive agents coupled to or repelled by a graft polymer (made, for example, from monomers such as N-(3-aminopropyl) methacrylamide hydrochloride (APMA), 2-acrylamido-2-methylpropane sulfonic acid (AMPS), acrylamide (AAm)m and acrylic acid (AA)) which is in turn bonded to a polymeric substrate surface. The articles are useful as thromboresistant and/or antimicrobial medical devices.

## Claims

### Claim 1

An article for use in contact with blood or blood products, the article including at least one biocompatible polymeric surface for contacting blood or blood products, the polymeric surface having thereon a first layer and a second layer, the first layer comprising a graft co-polymer grafted onto the polymeric surface by co-polymerizing a first vinyl monomer selected from the group consisting of 2-acrylamido-2-methylpropane sulfonic acid, acrylamide, acrylic acid, and 2-hydroxyethyl methacrylate with a second vinyl monomer of N-(3-aminopropyl) methacrylamide hydrochloride which provides the graft co-polymer with pendant primary amine groups, the second layer comprising a bioactive agent selected from the group consisting of antibiotics, antimicrobials, anticoagulants and albumin-binding dyes coupled to the graft co-polymer by coupling to its primary amine groups.

### Claim 2 (depends on 1)

The article of claim 1 wherein the bioactive agent is ionically coupled to the graft co-polymer.

### Claim 3 (depends on 1)

The article of claim 1 wherein the bioactive agent is covalently coupled to the graft co-polymer.

### Claim 4 (depends on 1)

The article of claim 1 wherein the bioactive agent is an antibiotic.

### Claim 5 (depends on 1)

The article of claim 1 wherein the polymeric surface is polyurethane.

### Claim 6 (depends on 1)

The article of claim 1 wherein the polymeric surface is polyetherurethane.

### Claim 7 (depends on 1)

The article of claim 1 wherein the graft copolymer includes 2-acrylamido-2-methylpropane sulfonic acid as the first vinyl monomer.

### Claim 8 (depends on 1)

The article of claim 1 wherein the bioactive agent is gentamycin.