# US 5,344,449 A · Intraocular lenses, fixation member assemblies and methods for making same > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 5,344,449 A - Document ID: US5344449A - Status: Granted - Kind: A - Application number: 08/088,066 - Filed: 1993-07-06 - Granted: 1994-09-06 - Earliest claimed: 1990-07-03 - Assignees: Allergan, Inc. - Inventors: F. Richard Christ; James E. Francese; Bernard F. Grisoni - Web page: https://patentgrep.com/patent/US5344449A ## CPC - B29D 11/023: {Implants for natural eyes} - A61L 27/14: Macromolecular materials - A61F 2002/1686: {Securing a filiform haptic to a lens body} - B29C 59/14: by plasma treatment {(plasma tubes per se H01J)} - B29D: PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE (making granules B29B9/00; making preforms B29B11/00) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - B29C: SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING (making preforms B29B11/00; making laminated products by combining previously unconnected layers which become one product whose layers will remain together B32B37/00 - B32B41/00) ## Abstract New intraocular lenses, fixation member assemblies for use in such lenses and methods for making the same are disclosed. In one embodiment, the present invention involves a method for producing a fixation member assembly which comprises exposing a fixation member component to a first plasma at conditions effective to enhance, relative to a substantially identical fixation member component which is not subjected to the exposing step, the bondability between the fixation member component and a polymeric coating to be located on the fixation member component; and exposing the fixation member to a second plasma in the presence of at least one material selected from polymeric components, polymerizable components and mixtures thereof at conditions effective to form the polymeric coating located on the fixation member component. Enhanced bondability between the polymeric coating-containing fixation member component and the optic of the intraocular lens and/or enhanced biocompatibility are preferably provided. ## Claims ### Claim 1 A method of producing a fixation member assembly to be bonded to an optic of in an intraocular lens comprising: exposing a lens bonding region of a fixation member component, which lens bonding region is to be bonded to the optic of the intraocular lens, to a plasma in the presence of at least one material selected from the group consisting of polymeric components, polymerizable components and mixtures thereof at conditions effective to form a polymeric coating located on said lens bonding region, the bondability between said lens bonding region with said polymeric coating located thereon and the optic of the intraocular lens of which it is to be a component is enhanced relative to a substantially identical lens bonding region which is not exposed to any plasma. ### Claim 2 (depends on 1) The method of claim 1 wherein said polymeric coating is bonded to said lens bonding region and which further comprises, prior to exposing said lens bonding region to said plasma, exposing said lens bonding region to a preliminary plasma at conditions effective to enhance, relative to a substantially identical lens bonding region which is not subjected to said preliminary plasma exposing step, the bondability between said lens bonding region and said polymeric coating to be located on said lens bonding region. ### Claim 3 (depends on 1) The method of claim 1 wherein said at least one material is organic and only said lens bonding region of said fixation member component is subjected to said exposing. ### Claim 4 The method of claim wherein said polymerizable components are selected from the group consisting of vinyl silanes, vinyl siloxanes hydride siloxanes, cyclic siloxanes, methacrylic acid esters, acrylic acid esters and mixtures thereof. ### Claim 5 (depends on 1) The method of claim 1 which, after exposing said lens bonding region to said plasma, further comprises exposing said lens bonding region with said polymeric coating locating thereon to a post-plasma at conditions effective to enhance, relative to a substantially identical polymeric coating-containing lens bonding region which is not subjected to said post-plasma exposing step, the bondability between said fixation member assembly and the optic of the intraocular lens. ### Claim 6 (depends on 2) The method of claim 2 which further comprises exposing said lens bonding region with said polymeric coating located thereon to a post-plasma at conditions effective to enhance, relative to a substantially identical polymeric coating-containing lens bonding region which is not subjected to said post-plasma exposing step, the bondability between said fixation member assembly and the optic of the intraocular lens. ### Claim 7 A method of producing a fixation member assembly for to be bonded to an optic of an intraocular lens comprising: contacting a lens bonding region of a fixation member component, which lens bonding region is to be bonded to the optic of the intraocular lens, with at least one material selected from the group consisting of polymeric components, polymerizable components and mixtures thereof at conditions effective to coat at least a portion of said lens bonding region with said at least one material; and exposing said coated lens bonding region to a plasma at conditions effective to enhance, relative to a substantially identical coated lens bonding region which is not subjected to said exposing step, the bondability between said lens bonding region and a polymeric coating derived from said coating located on said lens bonding region and to form a polymeric coating on said lens bonding region. ### Claim 8 (depends on 7) The method of claim 7 wherein said polymerizable components are selected from the group consisting of vinyl silanes, hydride silanes, vinyl siloxanes hydride siloxanes, cyclic siloxanes and mixtures thereof. ### Claim 9 (depends on 1) A fixation member assembly produced in accordance with claim 1. ### Claim 10 (depends on 2) A fixation member assembly produced in accordance with claim 2. ### Claim 11 (depends on 5) A fixation member assembly produced in accordance with claim 5. ### Claim 12 (depends on 6) A fixation member assembly produced in accordance with claim 6. ### Claim 13 (depends on 7) A fixation member assembly produced in accordance with claim 7. ### Claim 14 (depends on 9) An intraocular lens comprising: an optic; and at least one fixation member assembly of claim 9. ### Claim 15 (depends on 10) An intraocular lens comprising: an optic; and at least one fixation member assembly of claim 10. ### Claim 16 (depends on 11) An intraocular lens comprising: an optic; and at least one fixation member assembly of claim 11. ### Claim 17 (depends on 12) An intraocular lens comprising: an optic; and at least one fixation member assembly of claim 12. ### Claim 18 (depends on 13) An intraocular lens comprising: an optic; and at least one fixation member assembly of claim 13. ### Claim 19 (depends on 1) The method of claim 1 wherein said polymeric components are selected from the group consisting of vinyl polymers, hydride polymers, silicone polymers, polymers derived from methacrylic acid esters, polymers derived from acrylic acid esters and mixtures thereof. ### Claim 20 (depends on 7) The method of claim 7 wherein said polymeric components are selected from the group consisting of vinyl polymers, hydride polymers, silicone polymers, polymers derived from methacrylic acid esters, polymers derived from acrylic acid esters and mixtures thereof.