Nucleotide sequence encoding the tumor rejection antigen precursor, MAGE-1
AssigneeLudwig Institute for Cancer Research
InventorsThierry Boon, Pierre van der Bruggen, Benoit Van den Eynde, Aline Van Pel, Etienne De Plaen, Christophe Lurquin, Patrick Chomez, Catia Traversari
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Abstract
The invention relates to an isolated DNA sequence which codes for an antigen expressed by tumor cells which is recognized by cytotoxic T cells, leading to lysis of the tumor which expresses it. Also described are cells transfected by the DNA sequence, and various therapeutic and diagnostic uses arising out of the properties of the DNA and the antigen for which it codes.
Claims18
An isolated nucleic acid molecule which codes for the MAGE tumor rejection antigen precursor as set forth in SEQ. ID. NO. 8.
An isolated nucleic acid molecule which hybridizes to the nucleic acid molecule which codes for the MAGE-1 tumor rejection antigen precursor as set forth in SEO ID No:
- 8 under stringent conditions and which codes for a tumor rejection precursor.
Dependencies are inferred from the claim text.