Endocurietherapy
OwnerRoger R. Goodinventor
Life of this patent
Estimating the term…
Abstract
To provide versatile radioactive implants and methods of radiation therapy, plating methods such sputtering, as are used to coat single elements such as microspheres, wires and ribbons with radioactive metals, protective layers and identification layers. The resulting solid, radioactive, multilayered seamless elements are implanted individually or combined in intercavity applicators, with fabrics and in ribbons. Because they have selected half-lives and intensities, they provide flexibility in treatment, permitting low intensity or high intensity treatment, using temporary or permanent implants and implants with high intensity or low intensity or controured intensity to permit different therapies.
Claims55
A one-piece substantially spherical seamless multilayered radioactive seed, comprising:
- a microsphere including a central sphere and a layer section with no substantial voids between the central sphere and the layer section;
- said layer section including at least two layers concentric with the central sphere;
- said layer section being in intimate contact with the outer surface of the central sphere;
- a first layer of said at least two layers being an outer non-radioactive layer;
- at least one of said central sphere and layer section including radioactive material, wherein said microsphere has a therapeutic amount of radioactivity;
- and
- said microsphere having an outside diameter no greater than 1 millimeter.
A one-piece substantially spherical seamless multilayered radioactive seed, comprising:
- a microsphere including a central sphere and a layer section with no substantial voids between the central sphere and the layer section;
- said layer section including at least one layer concentric with the central sphere and in intimate contact with the outer surface of the central sphere;
- at least one of said central sphere and layer section including radioactive material wherein said microsphere has a therapeutic amount of radioactivity;
- said microsphere having an outside diameter no greater than 1 millimeter;
- said layer section further including a spherical coat designed to enhance diagnostic imaging.
A one-piece substantially spherical seamless multilayered radioactive microsphere, comprising:
- a microsphere including a central sphere and a layer section with no substantial voids between the central sphere and the layer section;
- said layer section including at least one layer concentric with the central sphere and in intimate contact with the outer surface of the central sphere;
- said microsphere having a therapeutic amount of radioactivity and an outside diameter no greater than 1 millimeter;
- the layer section including a radioactive coat;
- said radioactive coat being uniformly covered by a spherical diffusion barrier.
A one-piece substantially spherical seamless multilayered radioactive microsphere, comprising:
- a microsphere including a central sphere and a layer section with no substantial voids between the central sphere and the layer section;
- said layer section including at least one layer concentric with the central sphere and in intimate contact with the outer surface of the central sphere;
- at least one of said central sphere and layer section including radioactive material wherein said microsphere has a therapeutic amount of radioactivity;
- and
- said microsphere having an outside diameter no greater than 1 millimeter wherein the multilayer radioactive microsphere contains an inner spherical uniform coat of a material opaque to imaging rays, wherein the multilayer radioactive microsphere may be imaged by imaging means.
A one-piece substantially spherical seamless multilayer radioactive seed, comprising:
- a microsphere including a central sphere and a layer section with no substantial voids between the central sphere and the layer section;
- said layer section including at least one layer concentric with the central sphere and in intimate contact with the outer surface of the central sphere;
- at least one of said central sphere and layer sections including radioactive material, wherein said microsphere includes a therapeutic amount of radioactivity;
- and
- said microsphere including a significant amount of ferromagnetic material wherein the sphere may be moved by an externally applied electromagnetic field and apply a therapeutic amount or radioactivity to tissue;
- said microsphere having a diameter of between 1 millimeter and 9 millimeters.
A one-piece substantially spherical seamless multilayered radioactive microsphere, comprising:
- a microsphere including a central sphere and a layer section with no substantial voids between the central sphere and the layer section;
- said layer section including at least one layer concentrical with the central sphere and in intimate contact with the outer surface of the central sphere;
- said microsphere has a therapeutic amount of radioactivity and an outside diameter no greater than 1 millimeter;
- said microsphere having a ferromagnetic alloy that is capable of being inductively heated in situ by applied radiofrequency radiation until it passes through a Curie transition at temperatures useful for clinical hyperthermia.
A ribbon-multilayer radioactive unit having a plurality of substrate radioactive microspheres with outer diameters between 0.04 and 0.8 millimeters attached to a ribbon.
A multilayered seamless radioactive wire, comprising:
- a central wire section and a layer section;
- said layer section including at least three layers coaxial with the central wire section, said layer section being in intimate contact with the outer surface of the central wire section;
- at least one of said central wire section and layer section including radioactive material, wherein said wire has a therapeutic amount of radioactivity;
- and
- said wire having an outside diameter no greater than 1 millimeter.
A one-piece seamless multilayered radioactive ocular applicator, comprising:
- a substrate section and a layer section;
- said layer section including at least one layer in intimate contact with a surface of the substrate section;
- said applicator having a surface curved adapted to conform to a portion of the eye and containing a therapeutic amount of radioactivity in which radioactive multilayers in the layer section having a thickness no greater than 0.5 millimeters.
A radioactive applicator comprising:
- surgical factor containing multiple evenly-spaced multilayer radioactive microspheres;
- each of said microspheres being a one-piece substantially spherical seamless multilayered radioactive seed having a central sphere and a layer section;
- said layer section including at least one layer concentric with the central sphere and in intimate contact with the outer surface of the central sphere;
- at least one of said central sphere and layer section including radioactive material, wherein said microsphere has a therapeutic amount of radioactivity;
- and
- said microsphere having an outside diameter no greater than 1 millimeter.
A minituriazed intracavitary source comprising:
- a container having thin walls;
- a plurality of one-piece substantially spherical seamless multilayered radioactive seeds within said container;
- at least certain of said seeds including a central sphere and a layer section;
- said layer section including at least one layer concentric with the central sphere and in intimate contact with the outer surface of the central sphere;
- certain of said seeds having a therapeutic amount of radioactivity selected to cooperate with certain other of said seeds in said container and an outside diameter no greater than 1 millimeter;
- and
- said intracavitary source having an active length of between 10 millimeters and 40 millimeters.
An intracavitary applicator, comprising:
- a container having thin wall;
- said contained having an internal compartment with an internal diameter less than 1 millimeter and a length larger than 10 millimeters;
- said container including a closure wherein the container is adapted to receive and confine a plurality of removable radioactive elements for afterloading.
An intracavitary applicator according to claim 48 further including a plurality of one-piece substantially spherical seamless multilayered radioactive seeds having selected radioactivities whereby the container may be loaded to serve as a cervical intercavity applicator;
- each of said microspheres including a central sphere and a layer section;
- said layer section including at least one layer concentric with the central sphere and in intimate contact with the outer surface of the central sphere;
- at least one of said central sphere and layer section including radioactive material, wherein said microspheres having a therapeutic amount of radioactivity;
- said microspheres having an outside diameter no greater than 1 millimeter;
- and
- said applicator having an active length of between 10 millimeters and 40 millimeters.
A one-piece substantially spherical seamless multilayered radioactive seed, comprising:
- a microsphere including a central sphere and a layer section with no substantial voids between the central sphere and the layer section;
- said layer section including at least one radioactive layer concentric with the central sphere, said radioactive layer having a peak-to-valley height variation that does not exceed plus or minus 400 angstroms;
- and
- said microsphere has a therapeutic amount of radioactivity and an outside diameter no greater than 1 millimeter.
A ribbon-multilayer radioactive unit having a plurality of substrate radioactive microspheres with outer diameters between 0.04 and 0.08 millimeters attached to a ribbon;
- said microspheres having a radioactive layer;
- said radioactive layer having a peak-to-valley height variation that does not exceed plus or minus 400 angstroms.
A multilayered seamless radioactive wire, comprising:
- a central wire section and a layer section;
- said layer section including at least one radioactive layer coaxial with the central wire section;
- said radioactive layer having a peak-to-valley height variation that does not exceed plus or minus 400 angstroms;
- and
- said wire having a therapeutic amount of radioactivity and an outside diameter no greater than 1 millimeter.
A one-piece seamless multilayered radioactive ocular applicator, comprising:
- a substrate section and a layer section;
- said layer section including at least one radioactive layer, said radioactive layer having a peak-to-valley height variation that does not exceed plus or minus 400 angstroms;
- and
- said applicator having a therapeutic amount of radioactivity in which radioactive multilayers in the layer section having a thickness no greater than 0.5 millimeters.
A radioactive applicator, comprising:
- surgical fabric containing multiple evenly-spaced multilayer radioactive microspheres;
- each of said microspheres being a one-piece substantially spherical seamless multilayered radioactive seed having a central sphere and a layer section;
- said layer section being in intimate contact with the outer surface of said central sphere;
- said layer section including at least one radioactive layer concentric with the central sphere;
- said radioactive layer having a peak-to-valley height variation that does not exceed plus or minus 400 angstroms;
- and
- said microsphere having a therapeutic amount of radioactivity and an outside diameter no greater than 1 millimeter.
A miniturized intracavitary source, comprising:
- a container having thin walls;
- a plurality of one-piece substantially spherical seamless multilayered radioactive seeds within said container;
- at least certain of said seeds including a central sphere and a layer section;
- said layer section including at least one radioactive layer concentric with the central sphere;
- said radioactive layer having a peak-to-valley height variation that does not exceed plus or minus 400 angstroms;
- certain of said seeds having a therapeutic amount of radioactivity selected to cooperate with certain other of said seeds in said container and an outside diameter no greater than 1 millimeter;
- and
- said intracavitary source having an active length of between 10 millimeters and 40 millimeters.
Dependencies are inferred from the claim text.