# US 5,342,190 A · Apparatus for emplacing viscous material in a cavity

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- Number: US 5,342,190 A
- Document ID: US5342190A
- Status: Granted
- Kind: A
- Application number: 07/918,651
- Filed: 1992-07-22
- Granted: 1994-08-30
- Earliest claimed: 1992-07-22
- Assignees: Optex Biomedical, Inc.
- Inventors: James R. Salter
- Web page: https://patentgrep.com/patent/US5342190A

## CPC

- G01N 21/7703: {using reagent-clad optical fibres or optical waveguides (using measurement of total internal reflection or attenuated total reflection G01N21/552; optical fibres or waveguides per se G02B)}
- G01N 2021/7796: {Special mountings, packaging of indicators}
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

Apparatus are disclosed for introducing thick material into a small cavity, the apparatus in one aspect including a piston/cylinder device insertable into a block bore of a containment block, the block bore having the thick material therein for transfer to the piston bore, the piston then movable to expel the material from the piston bore into the cavity; in certain aspects the cavity of microscopic size and in other aspects thick material being a thixotropic chemical indicating material and the cavity extending through a fiber optic in a biosensor;

## Claims

### Claim 1

In a system for installing an amount of a thick chemical indicator complex comprising liquid chemical indicating substance immobilized on solid particles in a microscopic cavity extending through a fiber optic in a biosensor, the cavity having a cavity volume, wherein the improvement comprising
a block with a block bore therein for holding said thick chemical indicator complex,
a material handling assembly having means for partially inserting said assembly into the block bore, the material handling assembly having a body with a body bore therethrough and a piston movably positioned in the body bore,
the piston having means moving the piston for vacating a portion of the body bore so that upon insertion of the material handling assembly into the block bore an amount of the chemical indicator complex enters the vacated portion of the body bore, and
the piston having means moving the piston for expelling the amount of the chemical indicator complex into the cavity at a pressure sufficiently low to prevent the liquid chemical indicating substance from separating from the solid particles.

### Claim 2 (depends on 1)

The system of claim 1 wherein the microscopic cavity has a volume of five nanoliters or less.

### Claim 3 (depends on 1)

The system of claim 1 wherein the microscopic cavity is cubic with a side about 100 microns long.

### Claim 4 (depends on 1)

The system of claim 1 wherein the vacated portion of the body bore has a volume equivalent to the cavity volume.

### Claim 5 (depends on 1)

The system of claim 1 wherein the block bore has a depth and the piston has a diameter, and the block bore's depth is equal to five times the piston's diameter or less.

### Claim 6 (depends on 1)

The system of claim 1 wherein
the block is mounted on a block base having a guide groove therein, and
the material handling assembly has a base receivable in and movable in the guide groove.

### Claim 7 (depends on 6)

The system of claim 6 wherein
the piston is secured to a slide member which is movably positioned in a slide bore in a base of the material handling assembly and
the slide member is movable to thereby move the piston in the body bore so that a desired portion of the body bore is vacated.

### Claim 8 (depends on 7)

The system of claim 7 wherein
spring means is interconnected between the base of the material handling assembly and the slide member to push the slide member away from the block.

### Claim 9 (depends on 1)

The system of claim 1 wherein a movable block surface is movably secured to the block and positioned for blocking an end of the block bore opposite an end of the block bore into which the body of the material handling assembly is inserted.