# US 5,341,801 A · Inhaler > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 5,341,801 A - Document ID: US5341801A - Status: Granted - Kind: A - Application number: 07/983,012 - Filed: 1992-11-30 - Granted: 1994-08-30 - Earliest claimed: 1991-12-03 - Assignees: Sandoz Ltd. - Inventors: Kurt Zechner - Web page: https://patentgrep.com/patent/US5341801A ## CPC - A61M 15/0065: {Inhalators with dosage or measuring devices (A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52)} - A61M 11/002: {by flow deviation causing inertial separation of transported particles} - A61M 2202/064: Powder - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract An inhaler for delivering metered doses of a particulate drug. The inhaler is formed of a housing, a drug reservoir attached to the housing to contain multiple doses of the particulate drug, a drug transporting slide in the housing that contains a metering chamber of volume corresponding to a desired dose of the drug, and a vacuum pump that creates a partial vacuum in the metering chamber. The drug transporting slide is movable from a load position, in which it communicates with the drug reservoir to receive in its metering chamber drug from the drug reservoir, to a release position in which it communicates with an air outlet passage to release drug from the metering chamber into the air outlet passage. The drug reservoir has an air permeable portion that permits air flow into the drug reservoir but prevents drug escape. In use, the vacuum pump draws a dose of drug into the metering chamber. The drug transporting slide then moves to deposit the drug in the outlet passage for inhalation. ## Claims ### Claim 1 An inhaler for delivering metered doses of a particulate drug, the inhaler comprising a housing having an air inlet and an air outlet passage communicating with the air inlet for entraining the particulate drug in a stream of air traveling through said housing; a drug reservoir attached to the housing to contain multiple doses of the particulate drug, the drug reservoir having an air permeable portion that permits air flow into the drug reservoir but prevent drug escape; a drug transporting means in the housing that has a metering chamber of volume corresponding to a desired dose of the drug, the drug transporting means being operative between a load position, in which it communicates with the drug reservoir to receive in its metering chamber drug from the drug reservoir, and a release position in which it releases drug transported from the metering chamber into the air outlet passage; a vacuum generating means that creates a partial vacuum in the metering chamber of the drug transporting means when it is in its load position to draw drug into the metering chamber from the drug reservoir; and an acutator means connected to the drug transporting means and the vacuum generating means for causing movement of the drug transporting means to its load position and for simultaneously causing the vacuum generating means to create a partial vacuum. ### Claim 2 (depends on 1) An inhaler according to claim 1 in which the vacuum generating means comprises a piston which travels in a vacuum chamber in the housing and defines one wall of the vacuum chamber; the piston reducing the air pressure behind it as it increases the volume of the vacuum chamber. ### Claim 3 (depends on 1) An inhaler according to claim 1 in which the drug transporting means is a slide that slides reciprocatingly between its load position and its release position in a slide passage in the housing; the slide fitting snugly in the slide passage to prevent escape of drug. ### Claim 4 (depends on 3) An inhaler according to claim 3 in which the metering chamber is an aperture through the slide; one mouth of the aperture connecting to the drug reservoir and the opposite mouth of the aperture connecting to the vacuum generating means when the slide is in the load position. ### Claim 5 (depends on 2) An inhaler according to claim 2 in which the drug transporting means is a slide that slides reciprocatingly between its load position and its release position in a slide passage in the housing; the slide fitting snugly in the slide passage to prevent escape of drug. ### Claim 6 (depends on 5) An inhaler according to claim 5 in which the metering chamber is an aperture through the slide; one mouth of the aperture connecting to the drug reservoir and the opposite mouth of the aperture connecting to the vacuum generating means when the slide is in the load position. ### Claim 7 (depends on 5) An inhaler according to claim 5 in which the slide is connected to the piston so that the slide and piston move synchronously to provide the greatest vacuum when the slide reaches the load position. ### Claim 8 (depends on 7) An inhaler according to claim 7 in which a vacuum passage connects the slide passage to the vacuum chamber; the mouth of the vacuum passage in the slide passage being sealed by an air permeable filter to prevent the escape of drug from the metering chamber; and the opposite mouth of the vacuum passage opening into the vacuum chamber immediately before the position of furthest extension of the piston. ### Claim 9 (depends on 1) An inhaler according to claim 1 further comprising a biasing means to bias the drug transporting means to its release position. ### Claim 10 (depends on 1) An inhaler according to claim 1 further comprising baffles in the air outlet passage to promote entrainment of drug particles deposited in it. ### Claim 11 (depends on 1) An inhaler according to claim 1 in which the reservoir contains a powdered drug. ### Claim 12 (depends on 11) An inhaler according to claim 11 in which the powdered drug is suitable for the treatment of asthma by pulmonary inhalation.