# US 5,341,800 A · Medicament inhalation device and formulation

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- Number: US 5,341,800 A
- Document ID: US5341800A
- Status: Granted
- Kind: A
- Application number: 07/897,246
- Filed: 1992-06-11
- Granted: 1994-08-30
- Earliest claimed: 1989-05-31
- Assignees: Fisons Limited
- Inventors: Andrew R. Clark; John L. Hart
- Web page: https://patentgrep.com/patent/US5341800A

## CPC

- A61M 15/0065: {Inhalators with dosage or measuring devices (A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52)}
- A61M 2202/066: made from a compacted product by abrading
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

A method of compacting and administering a powdered inhalation medicament for use in an inhalation device includes compacting a body of loosely powdered inhalation medicament such that the degree of compaction is sufficient to hold the body together solely due to the force of compaction and placing the compacted body into the inhalation device and abrading the compacted body to obtain a plurality of unit doses of the medicament.

## Claims

### Claim 1

A method of administering a powdered inhalation medicament from an inhalation device comprising the steps of:
obtaining a tightly compacted body of powdered inhalation medicament having a predetermined shape and including an active ingredient having a particle size of from 1 to 10 microns, the degree of compaction being sufficient to hold said powdered inhalation medicament together solely due to the compaction such that said tightly compacted body will retain its shape and structural integrity upon handling;
placing said tightly compacted body in said inhalation device;
abrading said tightly compacted body in said inhalation device so as to sequentially obtain a plurality of unit doses of said powdered inhalation medicament from a single tightly compacted body.