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US 5,340,920 AGranted
Physiologically active porcine peptide (CNP-53)
AssigneeHisayuki Matsuo
InventorsHisayuki Matsuo, Kenji Kangawa, Naoto Minamino
Life of this patent
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Abstract
A peptide composed of 53 amino acid residues represented by the following amino acid sequence: (see SEQ ID NO: 1) ##STR1## and derivatives thereof represented by the following amino acid sequence: (see SEQ ID NO: 2) ##STR2## wherein X is as shown in the specification, are disclosed. These polypeptides are novel and have natriuretic and hypotensive actions.
Claims2
An isolated peptide represented by the following amino acid sequence:
- ##STR8## where (1)/(2), (3)/(4), (5)/(6), (7)/(8) and (9)/(10) are respectively bonded directly, and each of the cysteine residues (Cys) at positions 37 and 53 forms an intramolecular S-S bond (see SEQ ID NO. 1).
An isolated peptide represented by the following amino acid sequence:
- ##STR9## where (1)/(2) and (3)/(4) are respectively bonded directly;
- each of the cysteine residues (Cys) at positions 6 and 22 forms an intramolecular S-S bond;
- and X is selected from the group consisting of peptides represented by the following formula:
- ##STR10## where (1')/(2'), (3')/(4') and (5')/(6') are respectively bonded directly.
1 more element
Dependencies are inferred from the claim text.