US 5,340,849 A · Biodegradable in-situ forming implants and methods for producing the same

Abstract

A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.

Claims16

Dependent claims

A method of forming a solid implant in-situ within a living body, comprising the steps of:

a) mixing together effective amounts of a liquid acrylic-ester-terminated, biodegradable prepolymer of terminal acryloyl groups and a residue of an oligomer having terminal functional groups which react with acryloyl acylating groups and a curing agent to form a mixture in a liquid form;
and
b) delivering said mixture within said body while said mixture is in a liquid form so as to allow said prepolymer to cure to form said solid implant.

Dependencies are inferred from the claim text.

Facts

Application

07/788,032Filed 23 Dec 1991 · division

Priority

3 Oct 1988

Granted

23 Aug 1994

Term ends

Not estimatedThe source records don’t support an estimate.

Classification35 codes

A61K 9/0024
Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in…
A61K 47/34
Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates: macromolecular compounds obtained otherwise than by reactions only…
A61L 15/44
Use of materials characterised by their function or physical properties: medicaments
A61L 15/62
Use of materials characterised by their function or physical properties: compostable, hydrosoluble or hydrodegradable materials

Biodegradable in-situ forming implants and methods for producing the same

Life of this patent

Biodegradable in-situ forming implants and methods for producing the same

Life of this patent

Abstract

Claims16