Azavesamicols
AssigneeRegents of the University of Minnesota
InventorsSimon M. N. Efange, Stanley M. Parsons
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Abstract
The compounds are vesamicol (hydroxylated phencyclidine (PCP) isomer trans-2-(4-phenyl-piperidino)cyclohexanol) derivatives with anticholinergic properties termed herein "azavesamicols" in which the cyclohexyl group of vesamicol is replaced with a heterocycle of similar size, the piperidyl ring. The compounds bind to the vesamicol receptor, a cytoplasmically-oriented site on the cholinergic synaptic vesicle, which is associated with the vesicular transporter of acetylcholine.
Claims6
An anticholinergic compound of the structural formula:
- ##STR2## wherein R is:
- substituted or unsubstituted phenyl, benzyl or benzoyl
An anticholinergic compound of the structural formula:
- ##STR4## wherein R is:
- substituted or unsubstituted phenyl, benzyl or benzoyl.
Prezamicol ##STR6##
Trozamicol ##STR7##
Dependencies are inferred from the claim text.