Treatment of metallic surfaces using radiofrequency plasma deposition and chemical attachment of bioactive agents

A medical device having a biocompatible antithrombogenic metallic surface, comprising:

• a metallic surface having a biologically active treatment adhered thereto;
• said biologically active treatment including a coating of heptafluorobutylmethacrylate polymer having reactive groups thereon, and a biologically active agent covalently bonded to said reactive groups;
• whereby the biocompatible metallic surface, when implanted within a blood vessel, substantially prevents thrombus formation thereon while avoiding any significant interference of the development of endothelialization of the biocompatable metallic surface.

A medical device having a biocompatible antithrombogenic metallic surface, comprising:

• a metallic surface with a biologically compatible treatment adhered thereto;
• said biologically active treatment including a heptafluorobutylmethacrylate polymer coating adhered to said metallic surface, a spacer molecule covalently bonded to said polymer coating and a biologically active agent covalently bonded to said spacer molecule;
• whereby, the biocompatible metallic member, when implanted within a blood vessel, prevents substantial thrombus from occurring on its surface while not significantly interfering with endothelialization of said surface.