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US 5,336,264 AGranted
Situ prepared calcium phosphate composition and method
AssigneeNorian Corporation
InventorsBrent R. Constanz, Mark T. Fulmer, Bryan M. Barr
Life of this patent
Estimating the term…
Abstract
Setting times of calcium phosphate cement compositions are enhanced by the addition of phosphate or carbonate lubricant compositions. Methods for preparing the cement compositions are provided.
Claims14
A method for preparing a rapid setting calcium phosphate composition capable of rapidly setting up in a viable mammalian host, said method comprising:
- combining with mixing dry precursors for producing a calcium phosphate mineral composition, said precursors comprising a calcium source and a phosphoric acid source free of uncombined water;
- combining said combined precursors with a lubricant at a pH in the range of 6-11, wherein said lubricant comprises a member selected from the group consisting of phosphate and carbonate and is from about 15 to 70 weight percent of the total composition;
- to form a rapidly setting flowable composition.
A method for preparing a rapid setting calcium phosphate composition capable of rapidly setting up in a viable mammalian host, said method comprising:
- combining with mixing dry precursors for producing a calcium phosphate mineral composition, said precursors comprising a calcium source comprising tetracalcium phosphate and calcium carbonate and a phosphate source comprising at least one of monocalcium phosphate and orthophosphoric acid free of uncombined water;
- combining said combined precursors with a lubricant comprising a member selected from the group consisting of sodium phosphate and carbonate in a concentration ranging from 0.05 to 0.5M, said lubricant at a pH in the range of 6-11, wherein said lubricant is from about 15 to 70 weight percent of the total composition;
- a form a rapidly setting flowable composition.
Dependencies are inferred from the claim text.