Stable radiometal antibody immunoconjugates
AssigneeAssociated Universities, Inc.
InventorsRonnie C. Mease, Suresh C. Srivastava, Jean-Francois Gestin
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Abstract
The present invention relates to new rigid chelating structures, to methods for preparing these materials, and to their use in preparing radiometal labeled immunoconjugates. These new chelates include cyclohexyl EDTA monohydride, the trans forms of cyclohexyl DTPA and TTHA, and derivatives of these cyclohexyl polyaminocarboxylate materials.
Claims4
N-[methyl-(2-amidoethyl-ethyleneglycol succinimidylsuccinate]-trans-1,2-diaminocylo-hexane-N,N',N'-triacetic acid.
A compound of the formula ##STR11## wherein R is selected from the group consisting of ##STR12## and o is 1 to 6.
A compound of the formula ##STR13## wherein R is selected from the group consisting of ##STR14## and o is 1 to 6.
A compound of the formula ##STR15## wherein R is selected from the group consisting of ##STR16##
Dependencies are inferred from the claim text.