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US 5,334,728 AGranted
Dopamine receptor ligands and imaging agents
AssigneeThe Trustees of the University of Pennsylvania
InventorsHank F. Kung, Raymond Murphy
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Abstract
Novel CNS dopamine D-2 receptors, such as the compound 5-iodo-7-N-[(1-ethyl-2-pyrrolidinyl)methyl]carboxamide-2,3-dihydrobenzofur an, are disclosed. These compounds are useful as imaging agents for D-2 receptors in the human brain and exhibit good brain retention and in vivo stability.
Claims12
A compound selected from the group consisting of compounds of the formulas ##STR14## where X is selected from the group consisting of Sn(R).sub.3, Si(R).sub.3 and HgR;
- R is C.sub.1 -C.sub.5 alkyl;
- Y and Y' are independently selected from the group consisting of hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.5 alkenyl and C.sub.2 -C.sub.5 alkynyl groups;
- and
- A is an alkylene moiety of from two to eight carbon atoms.
1 more element
Dependencies are inferred from the claim text.