US 5,334,712 AGranted

Cyclic hydrocarbons with an aminoalkyl sidechain

AssigneeThe Upjohn Company

InventorsRoy A. Johnson, Gordon L. Bundy, Gilbert A. Youngdale, Douglas R. Morton, Donald P. Wallach, deceased

Life of this patent

Estimating the term…

Abstract

Provided are cyclic hydrocarbons of Formula I ##STR1## with an aminoalkyl sidechain that are useful for treating phospholipase A2 mediated conditions, diabetes, and obesity.

Claims5

Dependent claims

A compound of the formula

wherein Z is ##STR15## wherein the dashed line indicates that the 5-6 bond is saturated or unsaturated;
wherein D is CH.sub.3 ;
wherein E and J are hydrogen, or R.sub.5 O--;
wherein R.sub.5 is hydrogen, C.sub.1 -C.sub.3 alkyl, or HOCH.sub.2 CH(OH)CH.sub.2 --;
wherein X.sub.2 and X.sub.3 are hydrogen;
wherein X.sub.1 is NR.sub.1 ;
wherein R.sub.1 is ##STR16## -(phenyl)-CH.sub.2 -(3-pyridinyl) wherein R.sub.8 is hydrogen;
wherein R.sub.2 is hydrogen, or Cl.sub.1 -C.sub.3 alkyl;
wherein n is 0;
wherein r is 1-8;
and pharmacologically acceptable salts thereof.

8 more elements

Dependencies are inferred from the claim text.

Facts

Application: 07/976,751Filed 16 Nov 1992 · division
Priority: 18 Oct 1985
Granted: 2 Aug 1994
Term ends: Not estimatedThe source records don’t support an estimate.

Classification11 codes

C07J 51/00
Normal steroids with unmodified cyclopentahydrophenanthrene skeleton not provided for in groups c07j1/00
C07D 213/38
Radicals substituted by singly-bound nitrogen atoms: having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
C07F 9/224
Amides of acids of phosphorus: phosphorus triamides
C07F 9/2458
The amide moiety containing a substituent or a structure which is considered as characteristic: of aliphatic amines

Family

Serial788,995Parent of this continuation-in-part · filed 18 Oct 1985
Serial843,120Parent of this continuation-in-part · filed 24 Mar 1986
Serial117,851Parent of this division · filed 16 Jun 1987
Serial394,396Parent of this division · filed 15 Aug 1989
Serial657,721Parent of this division · filed 20 Feb 1991
US 5,196,524 AParent of this division · filed 23 Mar 1993
US 4,917,826 AParent of this division
US 5,334,712 AThis patent

From the US filing history. Foreign family members aren’t listed.

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Abstract

Provided are cyclic hydrocarbons of Formula I ##STR1## with an aminoalkyl sidechain that are useful for treating phospholipase A2 mediated conditions, diabetes, and obesity.

Facts

Application

07/976,751Filed 16 Nov 1992 · division

Priority

18 Oct 1985

Granted

2 Aug 1994

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

C07J 51/00
Normal steroids with unmodified cyclopentahydrophenanthrene skeleton not provided for in groups c07j1/00
C07D 213/38
Radicals substituted by singly-bound nitrogen atoms: having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
C07F 9/224
Amides of acids of phosphorus: phosphorus triamides
C07F 9/2458
The amide moiety containing a substituent or a structure which is considered as characteristic: of aliphatic amines

Family

Serial788,995Parent of this continuation-in-part · filed 18 Oct 1985

Serial843,120Parent of this continuation-in-part · filed 24 Mar 1986

Serial117,851Parent of this division · filed 16 Jun 1987

Serial394,396Parent of this division · filed 15 Aug 1989

Serial657,721Parent of this division · filed 20 Feb 1991

US 5,196,524 AParent of this division · filed 23 Mar 1993

US 4,917,826 AParent of this division

US 5,334,712 AThis patent

From the US filing history. Foreign family members aren’t listed.