Use of acyl phosphate esters in the modification of hemoglobin

Abstract

A process for the preparation of acyl phosphate esters of the formula I or salts thereof: ##STR1## wherein R and R.sup.1 are the same or different and represent a linear or branched alkyl group having up to 4 carbon atoms, phenyl or benzyl; n is an integer; when n is 1, R.sup.2 represents the group ##STR2## wherein R.sup.4 is a linear or branched alkyl, alkenyl or alkynyl, a cyclic alkyl, a cyclic alkenyl, or aryl which may be substituted by alkyl, alkenyl, alkynyl, aryl, arylalkyl, or arylalkenyl, or when n is at least 2, R.sup.2 represents the group ##STR3## wherein R.sup.4 is as defined above. Novel compounds of the formula I wherein n is at least 2, and modified hemoglobin obtained using the novel compounds are also provided.

Dependencies are inferred from the claim text.