Glycoprotein isolated from ganoderma having immunosuppressive activity
AssigneeMeiji Milk Products Co., Ltd.
InventorsHajime Tsunoo, Kousuke Kino, Akio Yamashita
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Abstract
Disclosed herein is a novel glycoprotein derived from Ganoderma mycelia. The glycoprotein is free of human hemagglutination ability, and has immunosuppressive activities and a molecular weight of 16,000-18,000 as measured by SDS gel electrophoresis or 12,000-16,000 as measured by tricin-SDS gel electrophoresis. The glycoprotein is produced by culturing Ganoderma mycelia, extracting the resultant Ganoderma mycelia with an aqueous solvent, and then purifying the resultant extract. An immunosuppressive agent containing an effective amount of the glycoprotein is also disclosed.
Claims10
A substantially pure glycoprotein isolated from Ganoderma lucidum mycelia, being free of human hemagglutination ability, and having immunosuppressive activities and a molecular weight of 16,000-18,000 as measured by SDS gel electrophoresis or 12,000-16,000 as measured by tricin-SDS gel electrophoresis.
A process for the production of a novel glycoprotein derived from Ganoderma lucidum mycelia, said glycoprotein being free of human hemagglutination ability and having immunosuppressive activities and a molecular weight of 16,000-18,000 as measured by SDS gel electrophoresis or 12,000-16,000 as measured by tricin-SDS gel electrophoresis, which comprises culturing Ganoderma mycelia, extracting the resultant Ganoderma mycelia with an aqueous solvent, and then purifying the resultant extract.
An immunosuppressive agent comprising an effective amount of a novel glycoprotein derived from Ganoderma lucidum mycelia, being free of human hemagglutination ability, and having immunosuppressive activities and a molecular weight of 16,000-18,000 as measured by SDS gel electrophoresis or 12,000-16,000 as measured by tricin-SDS gel electrophoresis.
Dependencies are inferred from the claim text.