Method of preventing NMDA receptor-mediated neuronal damage
AssigneeChildren's Medical Center Corporation
InventorStuart A. Lipton
Life of this patent
Estimating the term…
Abstract
Disclosed is a method for reducing non-ischemic NMDA receptor-mediated neuronal damage in a mammal by administering to the mammal a compound of the formula shown in FIG. 1 (or a physiologically-acceptable salt thereof), wherein R.sub.1 includes an amino group, R.sub.2 -R.sub.17 are independently H or a short chain aliphatic group comprising 1-5 carbons, and R.sub.4 and R.sub.10 also may (independently) be a halogen or an acyl group. Also disclosed is a screen for antagonists of NMDA receptor mediated neurotoxicity which have an enhanced prospect for being clinically tolerated and selective against such neurotoxicity.
Claims14
A method of treating a patient to reduce painful peripheral neuropathy comprising administering to said patient a compound of the formula below, wherein R.sub.1 comprises an amino group;
- R.sub.2 -R.sub.17 are independently H or a short chain aliphatic group comprising 1-5 carbons;
- and R.sub.4 and R.sub.10 may also be a halogen or an acyl group, or a physiologically acceptable salt thereof, in a concentration effective to cause such reduction. ##STR2##
Dependencies are inferred from the claim text.