US 5,334,617 A · Amino acids useful as inhibitors of the advanced glycosylation of proteins

Abstract

The present invention relates to compositions and methods for inhibiting protein aging. Accordingly, a composition is disclosed which comprises an agent or compound capable of inhibiting the formation of advanced glycosylation end products of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. Suitable agents are amino acids and their derivatives which contain an active nitrogen-containing group. Particular agents comprise lysine and mixtures thereof. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

Claims31

Dependent claims

A method for treating an animal to inhibit the formation of advanced glycosylation end products of a target protein within said animal, said method comprising administering to said animal an effective amount of a pharmaceutical composition, said pharmaceutical composition comprising an agent of the formula ##STR2## wherein R is selected from the group consisting of hydrogen;

lower alkyl, optionally substituted by one or two hydroxyl, thiol, phenyl, hydroxyphenyl, lower alkylthio, carboxy, aminocarboxy or amino groups;
and their biocompatible and pharmaceutically acceptable acid addition salts;
capable of reacting with the carbonyl moiety of the early glycosylation product formed by the initial glycosylation of said target protein, together with a carrier therefor.

Dependencies are inferred from the claim text.

Facts

Application

07/825,598Filed 27 Jan 1992 · continuation in part

Priority

19 Mar 1984

Granted

2 Aug 1994

Term ends

Not estimatedThe source records don’t support an estimate.

Classification34 codes

G01N 33/6842
General methods of protein analysis not limited to specific proteins or families of proteins: proteomic analysis of subsets of protein mixtures…
A61K 8/43
Containing nitrogen: guanidines
A61K 31/155
Amines: amidines , e.g. guanidine , isourea , isothiourea
A61K 31/195
Carboxylic acids, e.g. valproic acid: having an amino group

Family

Serial590,820Parent of this continuation-in-part · filed 19 Mar 1984

Serial798,032Parent of this division · filed 14 Nov 1985

Serial220,504Parent of this continuation-in-part · filed 18 Jul 1988

Serial481,869Parent of this division · filed 20 Feb 1990

Serial805,200Parent of this continuation-in-part · filed 10 Dec 1991

US 5,128,360 AParent of this division

US 4,665,192 AParent of this continuation-in-part

US 4,758,583 AParent of this division

US 5,334,617 AThis patent

From the US filing history. Foreign family members aren’t listed.

Amino acids useful as inhibitors of the advanced glycosylation of proteins

Life of this patent

Amino acids useful as inhibitors of the advanced glycosylation of proteins

Life of this patent

Abstract

Claims31